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Syringocystadenocarcinoma Papilliferum: A Case Report and Review of the Literature

Annals of Dermatology 2019년 31권 5호 p.559 ~ 562
 ( Lee Kyoung-Geun ) - Konyang University College of Medicine Department of Dermatology

 ( Choi Won ) - Konyang University College of Medicine Department of Dermatology
 ( Lim Joon-Soo ) - Konyang University College of Medicine Department of Dermatology
 ( Hahn Hyung-Jin ) - Konyang University College of Medicine Department of Dermatology
 ( Myung Ki-Bum ) - Konyang University College of Medicine Department of Dermatology
 ( Cheong Seung-Hyun ) - Konyang University College of Medicine Department of Dermatology

Abstract


Syringocystadenocarcinoma papilliferum (SCACP) is a rare malignant adnexal neoplasm, which is considered as a malignant counterpart of syringocystadenoma papilliferum (SCAP). Clinically, SCACP appears as a nodule, inflammatory plaque, or tumor. The lesion is usually covered with crusts, which are formed by secretion of the apocrine epithelial cells. Histologically, SCACP resembles SCAP, with cystic papillomatous invaginations connected to the skin surface by funnel-shaped structures lined by infundibular epithelium. The stroma of the tumor consists of a dense inflammatory infiltrate of plasma cells and lymphocytes. SCACP differs from SCAP in terms of the architectural and cytological features of the tumor cells, and is characterized by higher nuclear cytoplasmic ratio, nuclear irregularity, coarse chromatin, and increased mitotic activity. However, the immunohistochemical findings of SCACP vary. Since only 49 cases of SCACP have been reported in the English literature, the clinical and histologic characteristics of SCACP have not been fully established. Further studies on the diagnostic criteria for SCACP are warranted. Here, we report a rare case of SCACP and present a review of other relevant literature.

키워드

Sweat gland neoplasm; Syringocystadenocarcinoma papilliferum; Syringocystadenoma papilliferum
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