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Increased Expression of Interleukin-12 in Lesional Skin of Atopic Dermatitis Patients with Psoriasiform Features on Histopathology: An Immunohistochemical Study

Annals of Dermatology 2020년 32권 1호 p.31 ~ 37
임현정 ( Lim Hyun-Jung ) - Kyungpook National University School of Medicine Department of Dermatology

한만훈 ( Han Man-Hoon ) - Kyungpook National University School of Medicine Department of Pathology
 ( Lee Eun-Hye ) - Kyungpook National University School of Medicine Department of Dermatology
은동혁 ( Eun Dong-Hyuk ) - Kyungpook National University School of Medicine Department of Dermatology
김준영 ( Kim Jun-Young ) - Kyungpook National University School of Medicine Department of Dermatology
이원주 ( Lee Weon-Ju ) - Kyungpook National University School of Medicine Department of Dermatology
이석종 ( Lee Seok-Jong ) - Kyungpook National University School of Medicine Department of Dermatology
김도원 ( Kim Do-Won ) - Kyungpook National University School of Medicine Department of Dermatology
박태인 ( Park Tae-In ) - Kyungpook National University School of Medicine Department of Pathology
김상현 ( Kim Sang-Hyun ) - Kyungpook National University School of Medicine Department of Pharmacology
장용현 ( Jang Yong-Hyun ) - Kyungpook National University School of Medicine Department of Dermatology

Abstract


Background: Based on clinical and genetic differences, atopic dermatitis (AD) and psoriasis have been classified in two different diseases, but recently, some authors regarded them as in one spectrum. The histological similarities including epidermal hyperplasia between chronic stages of AD and psoriasis supports the presence of two diseases in one spectrum.

Objective: We investigated clinical and immunohistopathological characteristics of adult Korean patients with AD showing psoriasiform chronic dermatitis on histopathology.

Methods: In total, 59 Korean patients with chronic AD were enrolled. Clinical, laboratory, and histopathological features were compared between AD patients with psoriasiform features and those with non-psoriasiform chronic dermatitis features on histology. In addition, immunohistopathological characteristics were analyzed using antibodies for key regulatory and effector cytokines in psoriasis.

Results: Fifteen patients (25.4%) showed a more “psoriasiform” histological appearance. The lesions in patients with psoriasiform features often showed clearer boundaries and noticeable scaling. The interleukin (IL)-23 expression in the psoriasiform chronic dermatitis group was not different from that in the psoriasis group, but the IL-17 expression was less than that in the psoriasis group. In the case of IL-12, multiple dermal inflammatory cells with dendrites were stained in the psoriasiform chronic dermatitis group compared with the 2 other non-psoriasiform subgroups.

Conclusion: The results suggest that IL-12 secreted from dermal inflammatory cells might be one of the important factors associated with the formation of psoriasiform features in chronic AD. However, further studies are required to better define the specific role of IL-12.

키워드

Atopic dermatitis; Cytokines; Endophenotype; Psoriasis
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