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Attenuation of hyperoxic acute lung injury by Lycium barbarum polysaccharide via inhibiting NLRP3 inflammasome

Archives of Pharmacal Research 2019년 42권 10호 p.902 ~ 908
 ( Hong Cheng-Ying ) - Jinan University Second Clinical Medicine College Shenzhen People’s Hospital Department of Critical Care Medicine

 ( Zhang Hua-Dong ) - Jinan University Second Clinical Medicine College Shenzhen People’s Hospital Department of Critical Care Medicine
 ( Liu Xue-Yan ) - Jinan University Second Clinical Medicine College Shenzhen People’s Hospital Department of Critical Care Medicine
 ( Xu Yong ) - Jinan University Second Clinical Medicine College Shenzhen People’s Hospital

Abstract


Lycium barbarum polysaccharide (LBP), an active component from Goji berry which is a traditional Chinese medicine, has anti-inflammatory and antioxidant features. The aim of our study was to investigate whether LBP has any role in hyperoxia-induced acute lung injury (ALI). Using a murine model of hyperoxia-induced ALI, we investigate the effect of LBP on pulmonary pathological changes as well as Sirtuin 1 (SIRT1) and the nucleotide binding domain and leucine-rich repeat pyrin domain containing 3 (NLRP3) inflammasome. Exposure to 100% oxygen for 72 h in male C57BL/6 mice resulted in increased protein levels of tumor necrosis factor-α and interleukin-1β in lung tissues, and aggravated lung histological alterations. These hyperoxia-induced changes and mortality were improved by LBP. LBP markedly suppressed the activation of NLRP3 inflammasome both in vivo and in vitro. Moreover, LBP upregulated SIRT1 expression compared with vehicle-treated group. Importantly, knockdown of SIRT1 reversed the inhibitory effect of LBP on NLRP3 inflammasome activation in vitro. LBP meliorated hyperoxia-induced ALI in mice by SIRT1-dependent inhibition of NLRP3 inflammasome activation.

키워드

Lycium barbarum polysaccharide; Acute lung injury; Sirtuin 1; NLRP3
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