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Principles and applications of nanomaterial-based hyperthermia in cancer therapy

Archives of Pharmacal Research 2020년 43권 1호 p.46 ~ 57
 ( Kang Jin-Kook ) - Chung-Ang University College of Pharmacy

 ( Kim Jae-Chang ) - Chung-Ang University College of Pharmacy
 ( Shin Yu-Seon ) - Chung-Ang University College of Pharmacy
 ( Han Sang-Myung ) - Chung-Ang University College of Pharmacy
 ( Won Woong-Roeck ) - Chung-Ang University College of Pharmacy
 ( Her Jae-Won ) - Chung-Ang University College of Pharmacy
 ( Park June-Yong ) - Chung-Ang University College of Pharmacy
오경택 ( Oh Kyung-Taek ) - Chung-Ang University College of Pharmacy

Abstract


Over the past few decades, hyperthermia therapy (HTT) has become one of the most promising strategies to treat cancer. HTT has been applied with nanotechnology to overcome drawbacks such as non-selectivity and invasiveness and to maximize therapeutic efficacy. The high temperature of HTT induces protein denaturation that leads to apoptosis or necrosis. It can also enhance the effects of other cancer therapies because heat-damaged tissues reduce radioresistance and help accumulate anticancer drugs. Gold nanoparticles and superparamagnetic iron oxide with different energy sources are commonly used as hyperthermia agents. New types of nanoparticles such as those whose surface is coated with several polymers and those modified with targeting moieties have been studied as novel HTT agents. In this review, we introduce principles and applications of nanotechnology-based HTT using gold nanoparticles and superparamagnetic iron oxide.

키워드

Cancer therapy; Hyperthermia; Nanotechnology; Gold nanoparticle; SPIO
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