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Advances in colon-targeted nano-drug delivery systems: challenges and solutions

Archives of Pharmacal Research 2020년 43권 1호 p.153 ~ 169
 ( Naeem Muhammad ) - National University of Medical Sciences Department of Biological Sciences

 ( Awan Uzma Azeem ) - National University of Medical Sciences Department of Biological Sciences
 ( Subhan Fazli ) - National University of Medical Sciences Department of Biological Sciences
 ( Cao Jiafu ) - Pusan National University College of Pharmacy
 ( Hlaing Shwe Phyu ) - Pusan National University College of Pharmacy
이주호 ( Lee Ju-Ho ) - Pusan National University College of Pharmacy
임은옥 ( Im Eun-Ok ) - Pusan National University College of Pharmacy
정윤진 ( Jung Yun-Jin ) - Pusan National University College of Pharmacy
유진욱 ( Yoo Jin-Wook ) - Pusan National University College of Pharmacy

Abstract


Nano-drug delivery systems (NDDS) for colon-targeted drug delivery are an active area of research on local diseases affecting the colon, such as ulcerative colitis, Crohn’s disease, colon cancer, and for the delivery of peptide or protein drugs and vaccinations. In particular, targeted nano-drug delivery to the colon is advantageous for colon-specific diseases because nanoparticles can accumulate in diseased parts, improve the efficacies of therapeutics, and enable localized treatments, which reduces systemic toxicity. However, there are many hurdles, such as burst drug release, enzyme and acidic degradation of drug and carrier in the stomach, pH variations, mucus entrapment, and systemic uptake in the upper small intestine, which could challenge and compromise the successful delivery of NDDS to the colon. With advancements in NDDS, it may be possible to overcome these challenges leading to efficient drug delivery for colon-specific disorders. This review describes a few of the potential colon-specific drug delivery areas and the challenges faced by colon-targeted orally administered delivery systems, and provides an updated summary of recent advances in the development of orally administered NDDS for colon targeting, and the future advances in this research.

키워드

Nano-drug delivery; Colon-targeting; Colorectal cancer; Ulcerative colitis
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