medric medric
[닫기]
잠시만 기다려 주세요. 로딩중입니다.

Does the Time Interval from Biopsy to Radical Prostatectomy Affect the Postoperative Oncologic Outcomes in Korean Men?

Journal of Korean Medical Science 2019년 34권 37호 p.234 ~ 234
 ( Kim Sang-Jin ) - Veterans Health Service Medical Center Department of Urology

 ( Ryu Jae-Hyun ) - Veterans Health Service Medical Center Department of Urology
 ( Yang Seung-Ok ) - Veterans Health Service Medical Center Department of Urology
 ( Lee Jeong-Kee ) - Veterans Health Service Medical Center Department of Urology
 ( Jung Tae-Young ) - Veterans Health Service Medical Center Department of Urology
 ( Kim Yun-Beom ) - Veterans Health Service Medical Center Department of Urology

Abstract


Background: Prostate cancer (PC) is the second most common type of cancer in men worldwide and the fifth most common cancer among Korean men. Although most PCs grow slowly, it is unclear whether a longer time interval from diagnosis to treatment causes worse outcomes. This study aimed to investigate whether the time interval from diagnosis to radical prostatectomy (RP) in men with clinically localized PC affects postoperative oncologic outcomes.

Methods: We retrospectively analyzed data of 427 men who underwent RP for localized PC between January 2005 and June 2016. The patients were divided into two groups based on the cutoff median time interval (100 days) from biopsy to surgery. The associations between time interval from biopsy to surgery (< 100 vs. ≥ 100 days) and adverse pathologic outcomes such as positive surgical margin, pathologic upgrading, and upstaging were evaluated. Biochemical recurrence (BCR)-free survival rates were analyzed and compared based on the time interval from biopsy to surgery.

Results: Pathologic upgrading of Gleason score in surgical specimens was more frequent in the longer time interval group and showed marginal significance (38.8% vs. 30.0%; P = 0.057). Based on multivariable analysis, an association was observed between time interval from biopsy to surgery and pathologic upgrading (odds ratio, 2.211; 95% confidence interval [CI], 1.342?3.645; P = 0.002). BCR-free survival did not differ based on time interval from biopsy to surgery, and significant association was not observed between time interval from biopsy to surgery and BCR on multivariable analysis (hazard ratio, 1.285; 95% CI, 0.795?2.077; P = 0.305).

Conclusion: Time interval ≥ 100 days from biopsy to RP in clinically localized PC increased the risk of pathologic upgrading but did not affect long-term BCR-free survival rates in Korean men.

키워드

Prostate; Prostatectomy; Prostatic Neoplasms; Time Factors; Treatment Outcome
원문 및 링크아웃 정보
  
등재저널 정보