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The Association between the Apolipoprotein E Gene Polymorphism and All-cause Mortality in the Korean Population

Journal of Korean Medical Science 2019년 34권 40호 p.269 ~ 269
 ( Choi Chang-Kyun ) - Chonnam National University Medical School Department of Preventive Medicine

권순석 ( Kweon Sun-Seog ) - Chonnam National University Medical School Department of Preventive Medicine
 ( Lee Young-Hoon ) - Wonkwang University College of Medicine Department of Preventive Medicine
 ( Nam Hae-Sung ) - Chungnam National University College of Medicine Department of Preventive Medicine
 ( Park Kyeong-Soo ) - Mokpo Jung-Ang Hospital Cardiocerebrovascular Center
류소연 ( Ryu So-Yeon ) - Chosun University College of Medicine Department of Preventive Medicine
최성우 ( Choi Seong-Woo ) - Chosun University College of Medicine Department of Preventive Medicine
 ( Kim Hye-Yeon ) - Chonnam National University Hospital Gwangju-Jeonnam Regional Cardiocerebrovascular Center
 ( Shin Min-Ho ) - Chonnam National University Medical School Department of Preventive Medicine

Abstract


Background: Apolipoprotein E (APOE) gene polymorphism is associated with neurodegenerative and cardiovascular diseases. Although the effects of the gene differ by ethnic group, few studies have examined Asians. Therefore, the association between APOE polymorphism and mortality in Koreans was evaluated in this study.

Methods: This study population included participants from the Dong-gu and Namwon Studies. APOE genotypes were categorized as E2 (E2/E2 and E2/E3), E3 (E3/E3), and E4 (E3/E4 and E4/E4). Multivariate Cox proportional hazard models were constructed using the E3 allele as a reference.

Results: In the model adjusting for study site, age, gender, and lifestyle, the hazard ratio (HR) of mortality for those with the E4 allele was 1.08 (95% confidence interval [CI], 0.97?1.20), while that for those with the E2 allele was 0.84 (95% CI, 0.74?0.96). After adjusting for blood lipids to evaluate their mediating effects, the HRs of mortality for those with E4 and E2 alleles were 1.08 (95% CI, 0.97?1.20) and 0.80 (95% CI, 0.70?0.92), respectively. These associations were more evident in younger groups, with HRs of 0.70 (95% CI, 0.52?0.92) for the E2 allele and 1.25 (95% CI, 1.03?1.53) for the E4 allele.

Conclusion: In two large population-based cohort studies, the E2 allele was associated with a lower risk of mortality compared with the E3 allele, whereas the E4 genotype was not associated with mortality in Koreans.

키워드

Apolipoprotein E Cohort Studies; All-cause Mortality; Polymorphism
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