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Relationship of Vesical Pressure to Urine Formation

Yonsei Medical Journal 1962년 3권 1호 p.28 ~ 33
 ( Shin Shi-Woo ) - Transportation Hospital Seoul Department of Urology

홍사석 ( Hong Sa-Suk ) - 연세대학교 의과대학 약리학교실

Abstract


The influence of intravesica1 pressure on urine for-mation was studied in dogs and rabbits prepared with ureteral fistulae and in man following ureteral cathe-terization. Reduction of urinary output following distension of the bladder occurred in all except two dogs. The mean rate of reduction in sixteen dogs was 37.3±4.9 per cent. The response was not blocked by tetracaine applied to the bladder mucosa or by systemic hexamethonium. The renal blood flow showed a significant reduction following distension of the bladder. After denervation or celiac ganglionectomy, the reduction of urinary output or of renal blood flow was prevented in the ipsilateral kidney. Coloring of the renal cortex by intravenously injected indigo carmine does not occur in animals with distended bladders. Adrenaline and serotonin produced and enhanced the effect on the urinary response of the distended bladder. The injection of a small amount of blood or urine from animals with distended bladders into undistended animals produced a significant decrease in urine formation in the recipients. In five human subjects, a marked reduction of urine flow was noted following bladder distension. We conchlde that the intravesical pressure may regulate the formation of urine through a short vesico-renal reflex mediated by the celiac ganglion and through a long vesico-hypothalamic reflex which releases the antidiuretic hormone.

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