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Effects of Inhalation Anesthetics on the Myocardial Catecholamines and its Response to Norepinephrine

Yonsei Medical Journal 1966년 7권 1호 p.39 ~ 46
 ( Kim Wan-Sik ) - 연세대학교 의과대학

 ( Robb Ian S. ) - 연세대학교 의과대학 마취과학교실
 ( Lee Woo-Choo ) - 연세대학교 의과대학 약리학교실

Abstract


The data obtained from present experiments demonstrated that among several inhalation anesthetics, ether was the most irritable, resulting in marked irregularity of respiratory movement, and halothane depressed respiratory rate more than the other. The pulse rate and blood pressure were decreased marked1y in ether and the halothane anesthesia. the rate of beat of the isolated atria was not greately altered after anesthesia with ether or trichlore-thylene, while it was reduced after chloroform or halothane inhalation. The response of isolated atria to exogeneous norepinephrine was most prominent in the atria isolated from halothane anesthetized rabbits. Myocardial catecholamine contents were reduced uniformly after anesthesia with each anesthetics and most significantly with the halothane inhalation. From the above results, it may be concluded that the increasing cardiac activity with general inhalation anesthetics is closely related to the quantitative changes of the endogenous myocardial catecholamine contents.

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