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The Effect of Anoxia on the Amino Acid and Carbohydrate Metabolism of the Isolated Dog Brain

Yonsei Medical Journal 1967년 8권 1호 p.13 ~ 17
 ( Huh Kon ) - 미국 University Hospitals, Madison

 ( Gilboe David D. ) - 미국 University Hospitals, Madison
 ( Minsker David H. ) - 미국 University Hospitals, Madison

Abstract


The isolated dog brain was perfused for a period of 4 minutes with blood normal in all constituents, but pathologically low in oxygen in order to follow the metabolic response of the brain to anoxia.

During anoxic perfusion, the brain appears to subsist on the free amino acids in the brain and on glucose taken up from the perfusion blood. Oxygen uptake is relatively constant increasing temporarily immediately after anoxia. The lactic acid formed within the brain during anoxia is not released in any quantity; instead it appears to be metabolized in the brain following the period of anoxia causing a lower than norma1 uptake of glucose. Brain ATP and GrP levels decrease significantly, but not markedly indicating that the brain’s energy requirements are being partially met during anoxic perfusion.

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