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Comparison of Overt and Inapparent Influenzal Infection in Ferret

Yonsei Medical Journal 1968년 9권 1호 p.18 ~ 23
 ( Yang Yong-Tae ) - Yonsei University College of Medicine Department of Microbiology

Abstract


In relation (to the size of viral inoculum, influenzal infection in ferrets caused by the inoculation of a mouse-adapted subline of PR 8 strain of type A influenza virus was studied. The results are summarized as follows;
1) When ferrets were inoculated with a highly diluted virus (10^(-7)), a small proportion of them experienced inapparent infections and the rest of them escaped the infection.
2) With the increased size of viral inocula, there was a good correlation between the size of infecting doses and the frequency of overt infections in ferrets.
3) Nasal tissues were the main locus of viral multiplication in ferrets at 72 hours after viral inoculation. Viral multiplication in nasal tissues was demonstrated only in a small proportion of ferrets which were inoculated with a 10_7 dilution of virus; however, when the size of viral inoculum was increased above this level, all ferrets had viral growth in their nasal tissues.
4) The involvement of pulmonary tissues, viral growth in those tissues and the development. of gross lung lesions were significantly rare. There was no clear-cut relationship between the size of infecting doses and the frequency of such pulmonary involvements in ferrets.

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