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Extrapulmonary Oxygenation by Giving Hydrogen Peroxide by Enema

Yonsei Medical Journal 1969년 10권 2호 p.125 ~ 138
 ( Yun Duk-Jin ) - Yonsei University College of Medicine Department of Pediatrics Yonsei University College of Medicine

Abstract


An investigation of extrapulmonary oxygenation was made in dogs, rabbits and, finally, in a case of Tetralogy of Fallot using an intestinal perfusion of hydrogen peroxide (H₂O₂).
For a single administration, 0.4 per cent (H₂O₂) can be given safely by enema, in doses of 10 ml. J Kg. of body weight, this would give maximum oxygenation in both the portal vein and inferior vena cava without the formation of gas emboli. Concentrations higher than this caused gas bubbles in the portal vein. For serial administrations, 0.2 per cent H₂O₂ can be given by enema exchanging the intestinal contents at 10 to 15 minutes intervals. When given concomitantly with human whole blood, 1.0 ml./ Kg. of body weight, there is a pro-longed higher oxygenation in the portal vein, inferior vena cava and femoral artery. This concentation of H2O2 would not cause gas emboli in the portal vein. Although extrapulmonary oxygenation is possible by giving oxygen by enema, this method would cause too much abdominal distension. In experiments of death by suffocation, the group given H₂O₂ had doubled the duration of E.K.G. activity when compared with controls.
One patient with Tetralogy of Fallot, confirmed by clinical findings, X-ray studies, E. K. G. and cardiac
catheterization, who was not suitable for cardiac surgery because of low mentality, was selected for this study. 0.2 per cent H₂O₂10 ml. per Kg. of body weight by enema, exchanging intestinal con-tents at 30 minutes intervals, resulted in a marked elevation of the pO₂ in the venous blood and in the inferior vena cava. There was a disappearance of finger tip and toe tip cyanosis and flushing of the soles and palms was noted during - the procedure.

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