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On the Degranulation of Mesenteric Mast Cells caused by Morphine and Meperidine Hydrochloride in White Rate

Yonsei Medical Journal 1969년 10권 2호 p.153 ~ 161
이규식 ( Lee Kyu-Sik ) - Yonsei University College of Medicine Department of Anatomy

 ( Pak Soo-Yun ) - Yonsei University College of Medicine Department of Anatomy

Abstract


Histological studies were carried out on the -degranulation of mesenteric mast cells of white .-rats caused by injections of morphine hydrochloride -and meperidine hydrochloride intravenously, intra-
eritoneally, and by local injection of the rat´s .mesentery and the following conclusions were obtained.
1. In the groups of intravenous, intraperitoneal, :and local injections of morphine hydrochloride, _fairly significant degranulation of the mesenteric mast cell was observed, which was probably asso--ciated with the concomitant liberation of tissue .histamine derived from its source.
2. In the groups of intravenous and intraperi--toneal injections of meperidine hydrochloride, the :significant degranulation of the mesenteric mast -cell was recognized. However, the local injections -displayed no cytological change of the cell and no increased permeability of dermal capillaries was -observed at the injecting site.
3. The degranulation of the mesenteric mast cell followed by an administration of meperidine hydrochloride was effectively inhibited after an adrenalectomy.

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