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Fine Structure Alteration of Rat Liver induced by Nitrosohexamethylenamine

Yonsei Medical Journal 1970년 11권 1호 p.31 ~ 44
 ( Kim Chung-Sook ) - Yonsei University College of Medicine Department of Pathology

 ( Melvin Greenblatt ) - USA University of Nebraska College of Medicine The Eppley Institute for Research in Cancer

Abstract


The ultrastructural alterations in rat liver by feeding NHM(nitrosohexamethylenewine).
These are described at intervals of 10 days, 5 weeks, 11 weeks, 14 weeks, 19 weeks, and 22 weeks.
The group at 5 and 11 weeks showed hyper-plastic lesions but, no nuclear change.
There were dilated rough endoplasmic reticulum with detached ribosomes, and alteration of mitochondria.
The mitochondria showed a dense matrix which often included membranous materials.
In the 14, 19, and 22 week groups, it showed nodular lesion which had atypical cells, and it was observed that the nucleus were enlarged and nucleoli were segregated
The bile canaliculi were dilated and contained dense materials.

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