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Age at menarche and risk of colorectal adenoma

Korean Journal of Internal Medicine 2019년 34권 5호 p.998 ~ 1007
 ( Kim Nam-Hee ) - Sungkyunkwan University School of Medicine Kangbuk Samsung Hospital Preventive Healthcare Center

박정호 ( Park Jung-Ho ) - Sungkyunkwan University School of Medicine Kangbuk Samsung Hospital Department of Internal Medicine
박동일 ( Park Dong-Il ) - Sungkyunkwan University School of Medicine Kangbuk Samsung Hospital Department of Internal Medicine
 ( Sohn Chong-Il ) - Sungkyunkwan University School of Medicine Kangbuk Samsung Hospital Department of Internal Medicine
 ( Choi Kyu-Yong ) - Sungkyunkwan University School of Medicine Kangbuk Samsung Hospital Department of Internal Medicine
 ( Jung Yoon-Suk ) - Sungkyunkwan University School of Medicine Kangbuk Samsung Hospital Department of Internal Medicine

Abstract


Background/Aims: Limited data are available regarding the association between age at menarche and the risk of colorectal adenoma. Therefore, we aimed to evaluate the relationship between reproductive factors including age at menarche and the risk of colorectal adenoma.

Methods: A cross-sectional study was performed on asymptomatic female subjects who underwent colonoscopy between 2010 and 2014 as part of a comprehensive health screening program in Korea. The association between reproductive factors including age at menarche and the presence of adenomas was assessed using multivariate logistic regression analysis.

Results: Among 32,620 asymptomatic female subjects, the proportion of patients with menarche at 10 to 11, 12 to 13, 14 to 15, 16 to 17, and 18 to 19 years of age was 4.1%, 31.7%, 45.4%, 14.9%, and 4.0%, respectively. Age at menarche was not significantly associated with the risk of any adenoma (adjusted odds ratio [AOR], 0.99; 95% confidence interval [CI], 0.97 to 1.02; p = 0.500) or advanced adenoma (AOR, 0.98; 95% CI, 0.91 to 1.04; p = 0.468) after adjusting for confounding factors. Age at menarche was not significantly associated with the risk of adenoma even among similar age groups. In addition, parity, use of female hormones, and menopause were not associated with the risk of adenoma.

Conclusions: Age at menarche, parity, use of female hormones, and menopause were not significantly associated with the risk of colorectal adenoma. Our findings indicate that reproductive factors including age at menarche do not affect the development of colorectal adenoma.

키워드

Menarche; Reproductive history; Colon; Adenoma
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