medric medric
[닫기]
잠시만 기다려 주세요. 로딩중입니다.

Shen-Kang protects against tacrolimus-induced renal injury

Korean Journal of Internal Medicine 2019년 34권 5호 p.1078 ~ 1090
 ( Zhang Long Ye ) - Yanbian University Hospital Department of Nephrology

 ( Jin Jian ) - Catholic University College of Medicine Seoul St. Mary’s Hospital Transplant Research Center
 ( Luo Kang ) - Yanbian University Hospital Department of Nephrology
 ( Piao Shang Guo ) - Yanbian University Hospital Department of Nephrology
 ( Zheng Hai Lan ) - Yanbian University Hospital Department of Nephrology
 ( Jin Ji Zhe ) - Yanbian University Hospital Department of Nephrology
 ( Lim Sun-Woo ) - Catholic University College of Medicine Seoul St. Mary’s Hospital Transplant Research Center
 ( Choi Bum-Soon ) - Catholic University College of Medicine Seoul St. Mary’s Hospital Transplant Research Center
 ( Yang Chul-Woo ) - Catholic University College of Medicine Seoul St. Mary’s Hospital Transplant Research Center
 ( Li Can ) - Yanbian University Hospital Department of Nephrology

Abstract


Background/Aims: Evidence suggests that Shen-Kang (SK), a traditional Chinese herbal medicine, protects against various types of renal injury. In this study, we evaluated whether SK treatment confers renoprotection in a rat model of chronic tacrolimus (TAC) nephropathy.

Methods: Rats were treated daily with TAC (1.5mg/kg, subcutaneously) and SK (450 mg/kg, intravenously) for 4 weeks. The effects of SK on TAC-induced renal injury were assessed by measuring renal function, urine albumin excretion, histopathology, inflammatory cell infiltration, expression of profibrotic (transforming growth factor β1 [TGF-β1] and TGF-β inducible gene-h3 [βig-h3]) and proinflammatory cytokines, oxidative stress, and apoptotic cell death.

Results: Administration of SK preserved glomerular integrity (fractional mesangial area and Wilms tumor 1-positive glomeruli), attenuated tubulointerstitial fibrosis, and reduced the number of ectodermal dysplasia 1-positive cells, and this was paralleled by improved urine albumin excretion and renal dysfunction. At the molecular level, SK treatment suppressed expression of TGF-β1/Smad2/3, βig-h3, and proinflammatory cytokines. Oxidative stress and apoptotic cell death were significantly decreased with SK treatment, and apoptosis-related genes were regulated toward cell survival (active caspase-3 and the B-cell lymphoma-2/Bcl2-associated X [Bcl-2/Bax] ratio).

Conclusions: SK protects against TAC-induced renal injury.

키워드

Tacrolimus; Shen-Kang; Transforming growth factor beta1; Apoptosis; Oxidative stress
원문 및 링크아웃 정보
  
등재저널 정보
SCI(E)
MEDLINE
KCI
KoreaMed
KAMS