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Roles of mast cells in rheumatoid arthritis

Korean Journal of Internal Medicine 2020년 35권 1호 p.12 ~ 24
민홍기 ( Min Hong-Ki ) - Konkuk University Medical Center Department of Internal Medicine

김경운 ( Kim Kyoung-Woon ) - Catholic University College of Medicine Seoul St. Mary′s Hospital Conversant Research Consortium in Immunologic Disease
이상헌 ( Lee Sang-Heon ) - Konkuk University School of Medicine Department of Internal Medicine
김해림 ( Kim Hae-Rim ) - Konkuk University School of Medicine Department of Internal Medicine

Abstract


Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory arthritis, and the complex interaction and activation of innate and adaptive immune cells are involved in RA pathogenesis. Mast cells (MCs) are one of the tissue-resident innate immune cells, and they contribute to RA pathogenesis. In the present review, the evidence of the pathologic role of MC in RA is discussed based on human and animal data. In addition, the potential role of MC in RA pathogenesis and the research area that should be focused on in the future are suggested.

키워드

Arthritis, rheumatoid; Mast cell; Etiology
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