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無膵液 및 無膽汁狀態가 I^(131)-標識 中性脂肪및 脂肪酸의 吸收狀態에 미치는 影響에 關한 硏究

Studies of Absorption of I^(131)-Labelled Neutral Fat and Fatty Acid in Pancrcatic Fistula and Bile Duet Fistula

경북의대잡지 1964년 5권 1호 p.97 ~ 112
백의태 (  ) - 경북대학교 의과대학 생화학교실

Abstract


The present studies were carried out in order to observe the absorption of I´~´-labelled neutral fat and fatty acid in pancreatic and bile duct fistula.
Olive oil or oleic acid labelled with I´a´ were adminstered by a stomach tube to eKperimental dogs and radioactivity in peripheral blood, portal blood and thoracic lymph were measured every hour for 7 hours.
The curves were compared with thoso obtained from groups of animals with; fistula of the main pancreatic duct with simultaneous ligation of the additional duct, and gall bladder fistula by elimination of common bile duct.
Radioactivity of faces were measured every day for 5 days and co neared the rate of ahs~u-p_ tion with normal groups.
The results of this studies were su_umerized as follows:
1. The rate of absorption of I´~´-olive oil and I13´-oleic acid in normal groups were significantly high without any difference between then.
2. Absorption of It31-olive oil in the periphcral. blood was lower in bile duct fistula groups than in pancreatic fistula groups.
3. Z´he rate of absorption of I´~´-oleic acid was in absence of bile, however a little higher than that oi` I´a´-olive oil in bile duct fistula.
4. Radioactivity in the peripheral blood, after the administration of I´~´-olive oil, became lower in order of the groups of pancreatic fistula, bile duct fistula ant combined fistula of the pancreatico-bile due*,.
5. Kadioactivity of 1^131 olive oil in thoracic duct and portal blood was lower by elimination of bile from digestive process than lack of pancreatic accretion.
6. In absence of bile, absorption rate of [´~~-oleic acid of portal and periphcral blood was decreased similarly to the groups of I"´-olive oil, but radioactivity of I"´-oleic acid in the thoracic duct was higher than in I´~´-olive oil.
7. Radioactivity in both groups of i´~´-olive oil and. I´´-oleic acid was maximal in v or 6 hours ;after the administration and decreased gradually as time progressed.
8. Radioactivity of the thoracic duct in both groups of fat and fatty acid was constantly r or 8 times higher than in portal blood.

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