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胸腺이 Cortisone 및 四鹽化炭素에 對한 生體反應에 미치는 影響에 關한 實驗的硏究

Experimental studies of Effects of Thymus on Vital Reaction to Cortisone and Carbon tetrachloride

경북의대잡지 1966년 7권 2호 p.221 ~ 230
오태환 (  ) - 경북대학교 의과대학 병리학교실

Abstract


Vital reactions to cortisone and carbon tetrachloride in both thymectomized group and non-thymectomized group (control group) of young and adult rabbits were studied histopathotogically with the following results.
1) The body weight was decreased in both cortisone-administered and carbon tetrachloride-administered groups, but weight differences between the thymectomized group and the control group were not significant.
2) The histopathological changes of various organs resulting from the administration of massive doses of cortisone were more prominent in the thymectomized rabbits than those of the controls. However, no appreciable differences between young and adult rabbits were noted.
3) Hepatic degeneration, necrosis and fibrosis, resulting from administration of carton tetrachloride in the thymectomized young and adult rabbits were more marked than those in the control group. In the former group, histopathological changes such as increase of the hepatic glycogen, atrophy of the lymphoid tissues, decreased lipid in the adrenal cortices and atrophy of the thyroid glands were noted while the control group usually did not show such alterations. No remarkable difference between the young and adult rabbits was found.
4) Marked vital reactions to cortisone and carton tetrachloride were induced in the thymectomized rabbits and these effects of the thymus were noted in both young and adult rabbits.

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