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局所灌流化學療法이 人體에 미치는 影響에 關한 臨床的硏究

Clinical Studies on the Treatment of Cancer and Intractable Surgical Infection by Regional Perfusion

경북의대잡지 1967년 8권 2호 p.203 ~ 213
박종길 (  ) - 경북대학교 의과대학 외과학교실

Abstract


Twenty cases of various cancer and 10 cases of intractable surgical infection were perfused with chemotherapeutic agents utilizing an extra-corporeal circuit. Amounts of leakage during regional perfusion into the systemic circulation, and hematologic effects and liver functions following perfusions were observed.
Results were summarized as follows:
1. Leakages were 25% to 37% at 30 minutes after the onset of perfusion for lower and upper extremities where tourniquets were easily applied. However, in external carotid and pelvicareas where tourniquets were not applicable, leakages were high ranging from 75% to 92%.
2. Decrease of hemoglobin and red blood cell counts. was greater in the higher leakage group than that of lower leakage group. Transient increase of white blood cell counts in two days after perfusion was followed. by gradual decrease. but in two weeks, they recoverd to normal range. Platelets counts showed no significant charges.
3. Liver function tests showed almost no changes.

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