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白鼠에 있어서 肝葉切除後 再生期肝의 Hippuric Acid 合性 및 Sulfobromophthaleine의 膽管排泄에 關한 硏究

hippuric Acid Synthesis and Biliary Excretion of Sulfobromophthaleine in Rats after Partial Hepatectomy

경북의대잡지 1969년 10권 1호 p.171 ~ 175
정우 (  ) - 경북대학교 의과대학 생리학교실

류호열 (  ) - 경북대학교 의과대학 생리학교실

Abstract


Recovery of detoxifing and excretory functions of residual liver after partial hepatectomy (removed a´oout 70~/,~ of total liver) were studied by determining the detc:~ication of benzoic acid, as measured by the urinary excretion of hippuric acid, anyd biliary excretion of sulfobromo phthaleine.
In evaluating tha detoxication function, the ratio of urinary hippurate -C^14 to benzoate-C14 (H/B ratio) was also esti,::ated by thin layer chromatography after administration of sodium benzoate-C14 as a more significant criterion of the function than the amount of urinary hippurate (Choi and Ryoo: Kyungpook Med. J., 10:145, 1969).
Immediately after the partial hepatectomy, urinary H/B ratio showed about 2/5 of normal rats while the amount of urinary hippurate was decreased only to 2/3 of normal. The reduction of ]7/B ratio was more significant on 12 days pose: hepatectomy and gradually recovered through liver regeneration. Biliary excretion of intravenously in;ected sulfobromophthaleine also revealed more decrease ~2 days post-hepatectomy than immediate after the operation, but on 4 days post-hepatectomy the exretory function was alriost completely recovered.

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