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血淸의 C.albicans에 對한 抗菌作用의 實驗的 및 臨床的 硏究

Experimental and Clinical Studies of Anticandidial Action of Serum

경북의대잡지 1970년 11권 1호 p.23 ~ 34
서주익 (  ) - 경북대학교 의과대학 세균학교실

Abstract


For the purpose to evaluate the anticandidial effect of serum, rabbits were immunized with heat killed cells of C. albicans, and immune sera as well as immune sera absorbed with horn ologous or heterologous antigens were conducted antifungial survey as compared with control sera of .before immunization. On the other hand, rabbits were divided into three groups administering chloramphenicol, cortisone and chloramphenicol plus cortisone respectively, then sera of each rabbit from every group were ,surveyed for antifungial action.
Sera drawn from various malignant patients were also subjected to anticandidial survey in comparison with healthy persons.
1) Immune rabbit sera exhibited strong anticandidialaction as compared with the same :sera of before immunization, however, this -characteristic was by no means paralleled withthe titer of agglutinin. Anticandidial action of immune sera were removed by absorption with either h~~mologous or heterologous yeast antigens.
Anticandidial action of rabbit sera were not affected by cortisone injection, while some animals were deteriorated by chloramphenicol administration.
2) As for human sera, strong anticandidial action w~is equally found among healthy persons, however, in some cases among diabetes, oral thrush acid aplastic anemia, the activity was deteriorated. Among cancer patients, sera of few case;. of thyroid cancer were weakened in activity but iri many instances of the other kinds of cancer including stomach cancer and hepatoma, the anticandidial action of sera were deteriorated.

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