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角膜의 酸素擴散性에 關한 硏究

The Properties of Oxygen Diffusion in the Excised Cornea of the Rabbit and Dog

경북의대잡지 1970년 11권 1호 p.75 ~ 83
권달만 (  ) - 경북대학교 의과대학 안과학교실

Abstract


A series of experimental studies for diffusion rate, diffusion coefficient, permeation coefficient and diffusion capacity of the normal and pathological corneas of the rabbits and dogs were performed to investigate the diffusion properties of the cornea to oxygen with the gas diffusion apparatus devised by the auther, and following results were obtained.
The diffusion coefficient, permeation coefficient and diffusion capacity of the normal cornea were 1.16 X 10"~cm~/min, 2. i 1 X 10-7cm~/ min/atm, and 4.35X10-~m1/min/mmHg, respectively in the rabbit and 1.08X10-cm~/min, 3.95X10´7cm-/min/atm and 4.08X10-7m1/min/ mmHg respectively in the dog.
These values were lower than the values of diffusion coefficient of oxygen to the connective tissues of other animals. It is presumed that theses results were caused by histologic peculiarities of the corneal structures.
2. The diffusion capacity of oxygen was decreased while the diffusion and permeation coefficient increased in the edematous corneaproduced by injection of alloxan into the anterior chamber of the rabbit, and by the immersion i~ito the normal saline solution in the dog. These findings may be caused by thickenned cornea r~sulted by edema, which accounted for the lowering of the diffusion and for the increase of tine ratio of water content, that enabled more efficient gas diffusion in an unit thickness.
3. The diffusion capacity of oxygen in the neovascularized cornea of the rabbit was markedly lowered than that of the normal and the diffusion and permeation coefficient values were very high. It is specuated that the increase of the diffusion and permeation coefficient were due to the presence of blood in the cornea in which state the gas diffusion become more active than in water.
4. In the dried cornea of the dog, the diffusion c,~pacity vas higher and diffusion and permeation coefficient were lower than in the normal: presumably tj~e loss of water in the cornea v~ould be responsible for this results.

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