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Ethionme 長期投與가 生體에 미치는 影向에 關한 病理學的 硏究

Pathological Studies on Effects of Chronic Ethionine Feeding in Rats

경북의대잡지 1970년 11권 1호 p.109 ~ 118
정회교 (  ) - 慶北大學校 醫科大學 病理學敎室

洪錫辛 (  ) - 慶北大學校 醫科大學 病理學敎室

Abstract


The author studied morphological changes of various organs in albino rats of Sprague-Dowley strains, weighing between 1;0 to 330~;m, fed with basal diet (iSo protein) a:~d additi~oal 0.25 %D-L ethionine for G and 9 months, respectively ; and the following results were obtained:
1) The main lesions in the liver were fatty changes, necrosis, regenerative changes, appearance of atypical liver cells and hepatoma-like nodule; and marked proliferations of oval ducts and connective tissue (cholangiofibrosi~), and appearance of cholangioma-like nodules. Theses findings were more pronounced in 9-man thgroup than in 6-month-group.
2) The tumor-like lesions have not been developed in 6-month-group while in 5~-month-.group, the hepatoma-like nodules were identified in 4, out of 24 albino rats (16.7;0), and cholangioma-like nodules were noted in 10 out of 24 rats (42.7 o). These tumor-like nodules showed malignant characteristics histo;:ogicailybut no evidence of biological malignanc;~ such as distant metastases.
3) The 9-month-group shored marked shrinkage and fibrosis of glomexuli and necrosis of proximal convoluted tubules, and there was noted a mild degree of regenerative changes in tubular epithelium of the kidney.
4) The spleen showed atrophic changes in white pulp. The red pulp revealed a pulp cell hyperplasia and marked infiltrationof plasmatoid cell. The lymphnodes showed atrophic changes of follicles and marked plasma cell infiltrations.
5) The testis showed marked atrophic changes in seminifernus tubules of 3 or 4 degree by Kaufman´s grading.
6) The stmach revealed a definite degenerations of chief cells while the parietal cells were intact. The salivary gland and pancreas showed atrophic and destructive changes in acinar cells and intercalated ducts.

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