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Evaluation of the gastroprotective effects of 20 (S)-ginsenoside Rg3 on gastric ulcer models in mice

Journal of Ginseng Research 2019년 43권 4호 p.550 ~ 561
 ( Zhang Kai ) - Jilin University School of Pharmaceutical Sciences

 ( Wang Cuizhu ) - Jilin University School of Pharmaceutical Sciences
 ( Li Jiannan ) - Jilin University Second Hospital Department of General Surgery
 ( Liu Ying ) - Jilin University Second Hospital Department of General Surgery
 ( Xiong Lingxin ) - Jilin University School of Pharmaceutical Sciences
 ( Wang Zhenzhou ) - Jilin University School of Pharmaceutical Sciences
 ( Liu Jinping ) - Jilin University School of Pharmaceutical Sciences
 ( Li Pingya ) - Jilin University School of Pharmaceutical Sciences

Abstract


Background: Gastric ulcer (GU) is a common gastrointestinal disease that can be induced by many factors. Finding an effective treatment method that contains fewer side effects is important. 20 (S)-ginsenoside Rg3 is a kind of protopanaxadiol and has shown superior antiinflammatory and antioxidant effects in many studies, especially cancer studies. In this study, we examined the treatment efficacy of 20 (S)-ginsenoside Rg3 on GU.

Methods: Three kinds of GU models, including an alcohol GU model, a pylorus-ligated GU model, and an acetic acid GU model, were used. Mouse endothelin-1 (ET-1) and nitric oxide (NO) levels in blood and epidermal growth factor (EGF), superoxide dismutase, and NO levels in gastric mucosa were evaluated. Hematoxylin and eosin staining of gastric mucosa and immunohistochemical staining of ET-1, inducible nitric oxide synthase (NOS2), and epidermal growth factor receptors were studied. Ulcer index (UI) scores and UI ratios were also analyzed to demonstrate the GU conditions in different groups. Furthermore, Glide XP from Schrodinger was used for molecular docking to clarify the interactions between 20 (S)-ginsenoside Rg3 and EGF and NOS2.

Results: 20 (S)-ginsenoside Rg3 significantly decreased the UI scores and UI ratios in all the three GU models, and it demonstrated antiulcer effects by decreasing the ET-1 and NOS2 levels and increasing the NO, superoxide dismutase, EGF, and epidermal growth factor receptor levels. In addition, high-dose 20 (S)-ginsenoside Rg3 showed satisfactory gastric mucosa protection effects.

Conclusion: 20 (S)-ginsenoside Rg3 can inhibit the formation of GU and may be a potential therapeutic agent for GU.

키워드

Antiinflammation; Antioxidant; 20 (S)-ginsenoside Rg3; Gastric ulcer; Ulcer index
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