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Intraoral HIV-associated Burkitt’s lymphoma: a rare case report with special emphasis on differential diagnosis

대한구강악안면외과학회지 2019년 45권 4호 p.225 ~ 229
 ( Kamat Mamata ) - Bharati Vidyapeeth Deemed University Dental College and Hospital Department of Oral Pathology and Microbiology

 ( Datar Uma ) - Bharati Vidyapeeth Deemed University Dental College and Hospital Department of Oral Pathology and Microbiology
 ( Kanitkar Sampada ) - Private Clinic
 ( Byakodi Sanjay ) - Bharati Vidyapeeth (Deemed to be University) Dental College and Hospital Departments of Oral & Maxillofacial Surgery


Individuals with human immunodeficiency virus (HIV) infection present with unique intraoral manifestations of various neoplasms. Intraoral HIV-associated Burkitt’s lymphoma is a rare presentation, especially in patients of Indian origin and may present as an initial sign of HIV. The objective of this paper is to report a rare case of Burkitt’s lymphoma in an HIV-positive Indian patient along with a special emphasis on differential diagnosis. A 30-year-old Indian female presented with a solitary, well-defined, exophytic mass extending anteroposteriorly and buccolingually from the 35th to 38th regions with no evidence of intraosseous extension. An incisional biopsy was performed, and histopathology showed sheets of neoplastic lymphoid cells with numerous tingible body macrophages with clear cytoplasm, presenting a starry sky appearance, suggesting a diagnosis of BL. The tumor cells were positive for CD10, CD20, c-myc, and Epstein?Barr virus, with a nearly 100% Ki-67 proliferative index. The patient tested positive for HIV. This report indicates the importance of immunohistochemical analysis to differentiate Burkitt’s lymphoma from other similar lesions like diffuse large B-cell lymphoma. Thorough knowledge of the clinical presentation, etiopathogenesis, histopathology, and immunoprofile of intraoral HIV-associated Burkitt’s lymphoma is essential among clinicians and pathologists.


Aquired immunodeficiency syndrome; Burkitt lymphoma; Gingiva; HIV; Oral cavity
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