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백서 절치 맹출 관련 인자 발현에 대한 면역형광염색 연구

Localization of Eruption-Related Molecules in Developing Rat Incisors

대한구강해부학회지 2019년 40권 1호 p.1 ~ 8
한금동 ( Han Geum-Dong ) - 전남대학교 치의학전문대학원 구강해부학교실

심해경 ( Shim Hae-Kyoung ) - 전남대학교 치의학전문대학원 구강해부학교실
김세은 ( Kim Se-Eun ) - 전남대학교 치의학전문대학원 구강해부학교실
강지혜 ( Kang Ji-Hye ) - 전남대학교 치의학전문대학원 구강해부학교실
김민석 ( Kim Min-Seok ) - 전남대학교 치의학전문대학원 구강해부학교실
이은주 ( Lee Eun-Joo ) - 전남대학교 치의학전문대학원 구강해부학교실
김선헌 ( Kim Sun-Hun ) - 전남대학교 치의학전문대학원 구강해부학교실

Abstract


A complex and intricate cascades of gene expression is necessary for tooth development, and tooth eruption is one of main events during tooth development. Tooth eruption is considered to be strictly controlled either by signaling or extracellular molecules that are secreted by the tooth germs themselves. There have been numerous reports on the eruption-related molecules; however, there is still a lack of information regarding the preparation of the eruption pathway and the key tissue factors involved. This study aimed to localize the eruption-related molecules such as cyclophilin A (Cyp-A), extracellular matrix metalloproteinase inducer (EMMPRIN), matrix metalloproteinase proteins (MMP-9), receptor activator of nuclear factor kappa-B ligand (RANKL), and osteoprotegerin (OPG) in the developing rat incisors. Immunofluorescence findings revealed that Cyp-A, EMMPRIN, OPG, and RANKL were expressed strongly in the dental lamina epithelium of the rat incisor germs during eruptive movement. OPG was also expressed in the osteoclasts in the apical region. MMP-9, a final tissue resolution molecule, was more widely localized in the area surrounding the erupting incisor. This study suggested that the dental lamina epithelium may play a key role in preparing eruption pathways for the incisor in rats.

키워드

Cyp-A; EMMPRIN; OPG; RANKL; MMP; tooth eruption
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