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치주염 극복 및 기능적 재셍을 위한 발생생물학기반 치주질환모델

Disease models for the functional restoration of the periodontium based on developmental biology

대한구강해부학회지 2019년 40권 1호 p.9 ~ 18
아디카리 니르페쉬 ( Adhikari Nirpesh ) - 경북대학교 치과대학 구강생화학교실

아르알 얌 프라사드 ( Aryal Yam Prasad ) - 경북대학교 치과대학 구강생화학교실
안창현 ( An Chang-Hyeon ) - 경북대학교 치과대학 영상치의학교실
서조영 ( Seo Jo-Yeong ) - 경북대학교 치과대학 치주과학교실
안서영 ( An Seo-Young ) - 경북대학교 치과대학 영상치의학교실
김재영 ( Kim Jae-Young ) - 경북대학교 치과대학 구강생화학교실

Abstract


The tooth-supporting structures, which are collectively known as the periodontium, are disrupted in periodontal diseases. This disruption could lead to tooth loss at an advanced state. Therefore, the prevention and management of periodontal diseases are necessary to ensure a good quality of life. Different animal models are used to mimic the human periodontal disease conditions and examine the loss of tissues surrounding the teeth. The efficacy of various therapeutic compounds for the healing and regeneration of the disrupted structures were also examined. However, few studies have used animal models to examine the role of signaling molecules during the process of healing and regeneration. Since the signaling molecules play vital roles during the developmental processes, their role in the healing and regeneration of the periodontium must be evaluated based on the knowledge of developmental biology. This review highlights the process of periodontium development together with the role of signaling molecules. Furthermore, the disease conditions disrupting the periodontium and their severe consequences are also discussed. The different disease models commonly used for evaluation of the therapeutics and signaling molecules in periodontal diseases have also been reviewed, suggesting future research with a developmental biology approach in order to regenerate the periodontium

키워드

치아주위조직; 실험기법; 치주염; 치은염; 재생
Periodontium; Experimental model; Periodontitis; Gingivitis; Regeneration
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