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발생중인 생쥐 하악에서 tenascin-N 의 발현 양상

Expression patterns of tenascin-N in the developing mandible

대한구강해부학회지 2019년 40권 1호 p.43 ~ 49
장수샨 ( Zhang Sushan ) - 연세대학교 치과대학 구강생물학교실

박성호 ( Park Sung-Ho ) - 연세대학교 치과대학 구강악안면외과학교실
오상빈 ( Oh Sang-Bin ) - 연세대학교 치과대학 구강생물학교실
정영수 ( Jung Young-Soo ) - 연세대학교 치과대학 구강악안면외과학교실
이종민 ( Lee Jong-Min ) - 연세대학교 치과대학 구강생물학교실
정한성 ( Jung Han-Sung ) - 연세대학교 치과대학 구강생물학교실

Abstract


Previous studies have demonstrated that tenascin-N belongs to the family of tenascins, which are found in the extracellular matrix of various embryonic tissues, wounds, and tumors. Tenascin is expressed in the embryonic epithelium, including the neural epithelium from which neural crest cells emerge. However, the expression pattern and role of tenascin-N in the craniofacial region remains unknown. In this study, expression patterns of tenascin-N were confirmed in the mouse craniofacial region from embryonic day 12.5 (E12.5) to postnatal 11. In the diastema region, tenascin-N was strongly expressed in the mesenchyme from E12.5 to E14.5. Tenascin-N expression was also detected in the developing tooth germ. From the bell stage to the premature stage, tenascin- N was expressed in the odontoblasts and ameloblasts of the molar tooth germ, and the ameloblasts of the incisor tooth germ. These findings indicate that the spatial and temporal expression of tenascin-N might have a role in proper mouse craniofacial development, especially tooth development

키워드

Tenascin-N; 앞니; 치아간극; 어금니
Tenascin-N; incisor; diastema; molar
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