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상악동에 발생한 대세포 신경내분비 암종 1례

A Case of Large Cell Neuroendocrine Carcinoma of the Maxillary Sinus

대한두경부종양학회지 2019년 35권 2호 p.45 ~ 49
이윤재 ( Lee Yun-Jae ) - 한양대학교 의과대학 이비인후-두경부외과학교실

정진혁 ( Jeong Jin-Hyeok ) - 한양대학교 의과대학 이비인후-두경부외과학교실
오영하 ( Oh Young-Ha ) - 한양대학교 의과대학 병리학교실
지용배 ( Ji Yong-Bae ) - 한양대학교 의과대학 이비인후-두경부외과학교실

Abstract


Large cell neuroendocrine carcinoma is a rare epithelial neuroendocrine malignancy and is preferentially located in gastrointestinal tract and pancreas. Cases of large cell neuroendocrine carcinoma have been reported in many other locations, including the thymus, gallbladder, prostate, larynx, salivary glands, nasopharynx, tonsil and mastoid. However, primary sinonasal large cell neuroendocrine carcinoma never have been reported in Korea. We experienced a case of primary large cell neuroendocrine carcinoma arising from left maxillary sinus recently. A 82-year-old male patient presented with nasal obstruction and epistaxis. The biopsy revealed large cell neuroendocrine carcinoma with poor differentiation. After a general evaluation, the patient was staged as cT3N0M0. The patient was treated by combined radiotherapy and chemotherapy. We report this rare case with literature review.

키워드

Large cell neuroendocrine carcinoma; Paranasal sinus
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