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Alpha Adrenergic Blocking Agent가 Cyclopropane-Epinephrine 不整脈에 미치는 影響

Effect of Alpha Adrenergic Blocking Agent on Cyclopropane-Epinephrine Cardiac Arrhythmia in Dogs

대한마취과학회지 1969년 2권 1호 p.21 ~ 27
유명철 (  ) - 서울대학교 의과대학 마취과학교실

Abstract


1) Cardiac arrhythmias were produced in 8 mongrel dogs (weight, 13.3 ±1.5 kg) by injections of
epinephrine (0.032±0.0302 mg/kg) during inhalation of 25 per cent cyclopropane in oxygen.
2) Femoral arterial pressure was measured with a Statham transducer, and Lead I of the electrocardio-
gram recorded on a Sanborn Twin-Viso at a paper speed of 25 mm/sec.
3) Regitine (0.47±0.19 mg/kg), an alpha adrenergic blocking agent, significantly decreased the pressor response to epinephrine and consistently increased (4.8±1.8 times) the individual threshold doses of epinephrine required to produce cardiac arrhythmias.
4) In most instances the protective result was attributable to a modification by Regitine of the pressor effect of epinephrine.
5) It is concluded in the light that cyclopropane-epinephrine cardiac arrhythmias are blocked by alpha adrenergic blockade.

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