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Comparison of Brain Activation Images Associated with Sexual Arousal Induced by Visual Stimulation and SP6 Acupuncture : fMRI at 3 Tesla

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ÃÖ³²±æ ( Choi Nam-Gil ) - Àü³²´ëÇб³º´¿ø ¿µ»óÀÇÇаú

ÇÑÀ纹 ( Han Jae-Bok ) - µ¿½Å´ëÇб³ ¹æ»ç¼±°ú
À强ÁÖ ( Jang Seong-Joo ) - µ¿½Å´ëÇб³ ¹æ»ç¼±°ú
ÇÑÀ纹 ( Han Jae-Bok ) - µ¿½Å´ëÇб³ ¹æ»ç¼±Çаú
À强ÁÖ ( Jang Seong-Joo ) - µ¿½Å´ëÇб³ ¹æ»ç¼±Çаú

Abstract

¸ñ Àû: Á¤»óÀÎ ¿©¼ºÀ» ´ë»óÀ¸·Î ±â´ÉÀû ÀÚ±â°ø¸í¿µ»ó¹ý(functional magnetic resonance imaging : fMRI)À» ÀÌ¿ëÇÏ¿© ¼ºÀû ÈïºÐ¹ÝÀÀ°ú °ü·ÃµÇ´Â ½Ã°¢Àڱذú »ïÀ½±³(SP6, ß²ëäÎß) °æÇ÷ÀÚ±Ø ÀÇÇÑ ´ë³ú Ȱ¼ºÈ­ ¿µ¿ªÀÇ Â÷ÀÌÁ¡À» ¹àÈ÷°í, ³ª¾Æ°¡¼­´Â ¼ºÀûÈïºÐÀÇ ±âÀüÀ» ½Å°æÇغÎÇÐÀûÀÎ Ãø¸é¿¡¼­ ±Ô¸íÇϰíÀÚ ÇÏ¿´´Ù.

´ë»ó ¹× ¹æ¹ý: ¼º±â´ÉÀÌ Á¤»óÀûÀÎ ¿À¸¥¼ÕÀâÀÌ ¿©ÀÚ 21¸í(1932¼¼ : Æò±Õ 22¼¼)À» ´ë»óÀ¸·Î 3.0 Tesla MR scanner¸¦ ÀÌ¿ëÇÏ¿© fMRI ¿µ»óÀ» ¾ò¾ú´Ù. ¼ºÀû ÈïºÐÀ» À¯µµÇϱâ À§ÇÑ ÆÐ·¯´ÙÀÓÀº 3ºÐ°£ÀÇ ¿¡·Îƽ ºñµð¿À ½Ãû°ú »ïÀ½±³(SP6)ÀÚħ¿¡ ÀÇÇÑ ÀÚ±ØÀ» ÁÖ¾úÀ¸¸ç, ÀÚ±Ø Àü ÈÄ¿¡´Â °¢°¢ 1ºÐ°£ÀÇ ÈÞÁö±â¸¦ µÎ¾ú´Ù. ¶ÇÇÑ ±¤¸íÇ÷(GB37) ÈĹæÀ¸·Î 3 cm À§Ä¡¿¡ ÀÖ´Â ºñ°æÇ÷Á¡¿¡ ÀÚ±ØÀ» ÁÖ¾î °æÇ÷(acupoint)°ú ºñ°æÇ÷(shampoint) ÀÚħ¿¡ ÀÇÇÑ ´ë³úÀÇ È°¼ºÈ­ ¾ç»óÀ» ºñ±³ÇÏ¿´´Ù. ±â´ÉÀû ÀÚ±â°ø¸í¿µ»óÀÇ È¹µæÀº AC-PC lineÀ» ±âÁØÀ¸·Î 20°³ÀÇ È¾´Ü¸éÀ¸·ÎºÎÅÍ ÃÑ 2,000°³ÀÇ ±âÃÊ¿µ»óÀ» ¾ò¾úÀ¸¸ç, SPM99 ÇÁ·Î±×·¥À» ÀÌ¿ëÇÏ¿© Æò±Õ Ȱ¼ºÈ­ ¿µ»óÀ» ¾ò¾ú´Ù.

°á °ú: »ïÀ½±³ °æÇ÷°ú ºñ°æÇ÷ÀÇ Ä§Àڱؿ¡ ÀÇÇÑ ºñ±³½ÇÇè¿¡¼­ °æÇ÷Àº ºñ°æÇ÷¿¡ ºñÇÏ¿© ´ë³ú ½ÅÇÇÁú¿¡¼­ Æò±Õ 5¹è, º¯¿¬°è¿¡¼­ 2¹è ³ôÀº Ȱ¼ºÈ­µµ¸¦ º¸¿´´Ù. ºñ°æÇ÷ Àڱؽÿ¡ °£³úÀÇ HTHL, ±âÀúÇÙÀÇ GLO, AMYG, ±×¸®°í µÎÁ¤¿±ÀÇ SMG µî¿¡¼­´Â Ȱ¼ºÈ­ ½ÅÈ£°¡ °üÂûµÇÁö ¾Ê¾Ò´Ù. ¼ºÀûÈïºÐ°ú °ü·ÃµÈ ´ë³úÀÇ ÇØºÎÇÐÀûÀÎ ¿µ¿ªÀ» ½Ã°¢Àڱذú »ïÀ½±³ °æÇ÷ÀÚ±Ø º°·Î ºñ±³ ºÐ¼®ÇÑ °á°ú, µÎ Àڱذ£ÀÇ Æò±Õ Ȱ¼ºÈ­À²(activation ratio)Àº ½ÅÇÇÁú°ú º¯¿¬°è ¸ðµÎ¿¡¼­ À¯ÀÇÇÑ Â÷À̰¡ ¾ø¾ú´Ù(p < 0.05). ¹Ý¸é Æò±Õ Ȱ¼ºÈ­µµ(activity)´Â ½ÅÇÇÁúÀÇ °æ¿ì¿¡´Â µÎ Àڱذ£¿¡ À¯ÀÇÇÑ Â÷À̸¦ º¸ÀÌÁö ¾Ê¾ÒÀ¸³ª, º¯¿¬°èÀÇ °æ¿ì¿¡´Â °æÇ÷ Àڱؽÿ¡ À¯ÀÇÇÏ°Ô ´õ ³ôÀº Ȱ¼ºÈ­µµ¸¦ º¸¿´´Ù(p < 0.05).

°á ·Ð: ±â´ÉÀû ÀÚ±â°ø¸í¿µ»ó¹ýÀ» ÀÌ¿ëÇÏ¿© ¼ºÀûÈïºÐ°ú °ü·ÃµÈ ½Ã°¢Àڱذú °æÇ÷ ħ¼úÀڱؿ¡ ÀÇÇÏ¿© À¯¹ßµÈ ´ë³ú Ȱ¼ºÈ­ ¾ç»óÀÇ Â÷ÀÌÁ¡°ú ½Å°æÇغÎÇÐÀû ±âÀüÀÇ Â÷ÀÌÁ¡À» ±Ô¸íÇÒ ¼ö ÀÖ¾úÀ¸¸ç, ÀÌ·¯ÇÑ °á°ú¸¦ ¹ÙÅÁÀ¸·Î ÇâÈÄ ÇѹæÀÇ °æÇ÷, °æ¶ô ÀÌ·ÐÀ» °úÇÐÀûÀÎ Ãø¸é¿¡¼­ ÀÔÁõÇÒ ¼ö ÀÖÀ» °ÍÀ¸·Î ±â´ëÇÑ´Ù.

Purpose: This study was performed not only to compare the brain activation regions associated with sexual arousal induced by visual stimulation and SP6 acupuncture, but also to evaluate its differential neuro-anatomical mechanism in healthy women using functional magnetic resonance imaging (fMRI) at 3 Tesla (T).

Subjects and Methods : A total of 21 healthy right-handed female volunteers (mean age 22 years, range 19 to 32) underwent fMRI on a 3T MR scanner. The stimulation paradigm for sexual arousal consisted of two alternating periods of rest and activation. It began with a 1-minute rest period, 3 minutes of stimulation with either of an erotic video film or SP6 acupuncture, followed by 1-minute rest. In addition, a comparative study on the brain activation patterns between an acupoint and a shampoint nearby GB37 was performed. The fMRI data were obtained from 20 slices parallel to the AC-PC line on an axial plane, giving a total of 2,000 images. The mean activation maps were constructed and analyzed by using the statistical parametric mapping (SPM99) software.

Results: As comparison with the shampoint, the acupoint showed 5 times and 2 times higher activities in the neocortex and limbic system, respectively. Note that brain activation in response to stimulation with the shampoint was not observed in the regions including the HTHL in the diencephalon, GLO and AMYG in the basal ganglia, and SMG in the parietal lobe. In the comparative study of visual stimulation vs. SP6 acupuncture, the mean activation ratio of stimulus was not significantly different to each other in both the neocortex and the limbic system (p < 0.05). The mean activities induced by both stimuli were not significantly different in the neocortex, whereas the acupunctural stimulation showed higher activity in the limbic system (p < 0.05).

Conclusions : This study compared the differential brain activation patterns and the neural mechanisms for sexual arousal, which were induced by visual stimulation and SP6 acupuncture by using 3T fMRI. These findings will be useful to understand the theory of traditional acupuncture and acupoint channel in scientific point of view.

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±â´ÉÀû ÀÚ±â°ø¸í¿µ»ó¹ý; ½Ã°¢ÀÚ±Ø; »ïÀ½±³
functional magnetic resonance imaging (fMRI); visual stimulation; SP6
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