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화상이 생쥐의 간 및 신의 단백대사에 미치는 영향

Autoradiograrhic Studies of Early Incorporation of L-Leucine-U-l4C into the Liver and the Kidney of Burned Mice

대한병리학회지 1970년 4권 2호 p.99 ~ 105
송인석 (  ) - 가톨릭대학교

조형래 (  ) - 가톨릭대학 의학부 병리학교실

Abstract


Since the Cuthbertson's report that traumatic injuries caused a marked increase of
non-protein nitrogen in the urine, it has been generally believed that the traumatic
injuries enhanced the catabolism of the body, and this increased catabolism was induced
by the secretion of corticoids following trauma. However, it has also been known that
traumatic injuries stimulate and increase the anabolism as well as catabolism(Whipple).
Investigations have been carried out by the members of our department on the
mechanism of the inversion of albumin globulin ratio of plasma protein and the elevation
of plasma fibrinogen after burn. According to Lee and Kim(1969), the inversion of
albumin-globulin ratio of plasma protein after burn is due to the increased synthesis of
albumin and its accelerated "turn-over rate, and the coincidental decreased synthesis of
fibrinogen and its retarded turn-over rate.
On the other hand, it is well known that both albumin and fibrinogen are produced
solely in the liver. Lee(1968) in our laboratories reported that the marked decrease of the
incorporation rate of DL-lysine-T(G) into the liver protein in the burned rats, and Kim
and Kim (1969) reported that in the burned mice the incorporation rate of
L-leucine-U-l4C into the liver protein reached its maximum only 5
minutes after the injection and the curve for the changes of the incorporation rate of
L-leucine-U-l4C into the liver protein plotted against time showed the
same pattern as in the normal mice.
The authors performed the autoradiographic- observation on the incorporation rate of
L-leucine-U-l4C into the liver cells and the renal tubular cells in both of
normal and burned mice, to confirm of Kim's studies morphologically.
The following results were obtained:
1. In the burned mice, the labeled rate of L-leucine-U-l4C into the liver
cell reached its maximum later than that in the normal mice, on the other hand, in the
renal tubular cells the results were in opposite.
2. In the burned mice, the maximum number of grain of
L-leucine-U-l4C reached earlier than that in the normal mice, on the other
hand, in the renal tubular cells the inverse results were showed

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