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Arrhenoblastoma의 1例

Arrhenoblastoma of the Ovary with a Case Report

대한산부인과학회지 1961년 4권 2호 p.79 ~ 87
박재일 (  ) - 서울대학교 의과대학 산부인과학교실

Abstract


The author has submitted a case report of arrhenoblastoma of the ovary of a 36 year-old, married, nulliparous Korean woman. She complained of amenorrhea since 28 years of age, accompanied by atrophy , of the breasts and external genitalia, and deepening of her voice. Her clitoris became hypertrophied. Hair, growth of, male type occured over the body and face. Although, there was almost no change in her character, her libido was said to have been more active after cessation of her menstruation. Loss of weight and general weakness became. gradually marked. She eventually felt abdominal fullness and discomfort.
A tumor of the right ovary was treated by unilateral oophorectomy. Gross pathology of the tumor removed:
Right solid ovarian tumor.
Size; 5.5 X 8.0 x 10.0 cm
Weight; 200 gm.
Shape; oval-shaped.
Capsule; well encapsulated with glistening, translucent and serous capsule with an irregular surface.
Cut surface; pale yellow in general, grayish whitish. in places.
Consistence: rubbery, several-fingertip-sized hard nodules could be palpated in the tumor. Microscopic findings of the tumor
The specimen showed a tubular and adenomatous pattern. The tubular formation in general was not perfect and not resemble testicular tubules. In some areas the tubular formation wasj difficult to identify. The specimen was almost replaced by tumor cells.
Under the high magnification the nuclei of the individual cells were large and hyper-and polychromatic and differed greatly in size.
A great many vacuoles of various size in. nuclei were noted.
Microscopic diagnosis: Arrhenoblastoma, intermediate type.
Two months following operation she showed refeminization.
On arrhenoblastoma, historical considerations, histogenesis, pathology, clinical symptoml and signs, it´s relationship to pregnancy, malignity and recurrence, hereditary relationship, hormone; secretion of the tumor and it´s treatment were briefly discussed.

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