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保存血液에 關한 血液學的 및 生化學的硏究

Hematological and Biochemical Studies on the Preserved Blood

대한산부인과학회지 1962년 5권 2호 p.19 ~ 24
강치명 (  ) - 서울대학교 의과대학 산부인과학교실

Abstract


Since the Korean War, many blood banks have been established in Korea. Although they -have made a. great contribution to the medical practice, unexpected untoward side effects following transfusion of, the preserved whole blood were not infrequently experienced.
The Author-studied the hematological and biochemical changes, as well as the than e of coagulability of the preserved whole blood in an attempt to clarify the cause of those adverse side effects.
The hematological and biochemical changes were observed in the preserved blood in ACD. For the change of coagulability, the blood preserved in ACD and EDTA solution (25 ml.respectively for 100 ml. of blood) and heparinized blood (5 ml. of heparin for 100 ml, of blood) were used.
Prothrombin time, recalcification time and heparin tolerance test were employed for coagulability test.
1) The erythrocyte count of the preserved blood decreases gradually, but its decrease is not so remarkable until after three weeks of preservation.
2) Erythrocyte sedimentation rate retards gradually and after two weeks of preservation almost no change in sedimentation is observed.
3) Hematocrit of the blood increases as the time goes on, but not remarkably.
4) Leucocytes and blood platelets decrease markedly within a week after storage of the blood.
5) Potassium, cholesterol and inorganic phosphorus in the plasma increase.
6) On the contrary, glucose, fibrinogen and sodium in the plasma decrease.
7) protein in the plasma are almost invariably unchanged.
8) Coagulability of the preserved blood in various solutions decreases in general. Tae preserved blood in ACD and EDTA solutions show gradual decrease in the coagulability tests.
On the other hand, the coagulability of the heparinized blood is so rapidly decreased that it becomes inert to any coagulability tests in five days.

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