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사람 Trophoblast 機能에 關한 硏究

Studies on the Function of Early Human Trophoblast

대한산부인과학회지 1963년 6권 6호 p.15 ~ 18
김두상 (  ) - 전남대학교 의과대학 산부인과학교실

Abstract


In an attempt to elucidate the function of early human trophoblast and to find to find an enzymatic difference in normal pregnancy and abnormal pregnancy of hydatidiform , moles, activities of lactic dehydrogenase (LDH) and alkaline phosphatase (AP) in the maternal serum and the fluid of hydatidiform moles were measure and comparisons were made with those of normal non-pregnant and pregnant women.
1) Both of the than enzyme activities in the maternal sera of hydatidiform moles sowed slighly higher than pregnant, yet close to non-pregnant levels,: which suggests that enzymatic patterns in hydatidiform moles are more similar to those in non-pregnancy than in pregnancy.
2) Very high activities of both enzymes were demonstrated in the mole fluid. However´, existed a great variation in their enzyme contents among different moles. Thus, LDH in the mole fluid showed from 3 to 300-fold higher, and AP 2 to 30-fold higher activities than those´, of the maternal sera. It was suggested that this variation in the enzyme contents of mole fluid might reflect a possible existence of quantitative difference -among different moles in glycolytic metabolism of early trophoblast.
3) During the entire period of pregnancy, both LDH and AP serum levels were lower! than those in .non-pregnancy. However, upon delivery and until 48 hours after delivery these lowered enzyme levels were increased near to and/or above normal non-pregnant levels with a greater magnitude of the increase in AP activities.

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