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晩期妊娠中毒症에 있어서 血淸蛋白 및 尿蛋白의 Agar-Gel Micro-Electrophoresis에 依한 分劃的硏究

On the Agar-Gel Micro-electrophorectic Pattern of Serum and Urinary Protein in Late Toxemia of Pregnancy

대한산부인과학회지 1965년 8권 9호 p.13 ~ 17
안영국 (  ) - 서울대학교 의과대학 산부인과학교실

Abstract


The present study was undertaken for the purpose of determining the pattern of urinary protein excretion in pre-eclampsia and eclampsia condition and for evaluating this technique as a mean for their differentiation.
The serum and urine collection was done simultaneously from 13 pre-eclampsia and eclampsia patient before any medication.
Urine specimens have been concentrated to 20-40 folds using cellophane tube and 25% P.V.P. solution: The electrophorectic separation of urinary and serum protein was carried out simultaneously by modified
Wiere´s method. The results were as follows:
1) The fall in .serum total protein, albumin, and rise in total globulin, especially ca-globulins, were observed in toxemia cases in comparison with normal pregnancy at term.
2) The urine protein fractionations contained all the corresponding serum protein components and showed no evidence of special protein present or absence of certain fraction.
3) In the integral curve of urine protein fractionation, albumin and -globulin peaks were higher than corresponding serum samples, and typical peak of ?-globulin was prominent.
4) The more severe was proteinuria, the more promient was urinary al-globulin.
5) Correlation between serum protein & urinary excreted protein was statistically significant at the 5 %. level of significance in all fractions, and it is presumed -that mechanism of proteinuria in, toxemia is probably due to increased glomerular capillary permeability and decreased selective re-absorption from renal tubule by unknown toxemia factors.

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