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螢光顯微鏡에 依한 子宮癌細胞檢査

Cytological Screening of Uterine Cancer by Fluorescent Microscopy

대한산부인과학회지 1970년 13권 6호 p.19 ~ 24
安在榮 (  ) - 延世大學校 醫科大學 産婦人科學敎室

宋燦浩 (  ) - 延世大學校 醫科大學 産婦人科學敎室

Abstract


The authors have compared the relative accuracy of cervicovaginal screening for malignant cells using a fluorescent method and the traditional Papanicolaou method.
Duplicate smears were taken from 3,181 random patients ´in the clinics of the Department of Obstetrics and Gynecology, stained by the traditional Papanicolaou method and the Acridine orange method popularized by Riva and Turner.
Different members of the Department of Pathology read the regular smears while the fluorescent method was used by the authors. The patients with abnormal smears (Class ill, N and y) were subjected to tissue diangosis by either multiple biopsy or cold knife conization.
1. Among the 3,181 patients, an abnormal smear was found in 76 patients (2.39%) by the flourescent.method and 89 patients (2.79%) by the Papanicolaou method.
2. Tissue diagnosis was obtained in 36 patients out of 76 abnormal smears found by the fluorecesnt method and 41 patients out of 89 abnormal smears found by the Papanicolaou method. Analysis revelaled that the ratio of benign to malignant was 12 ~ 24 by the fluorescent method and 20 : 21 by the Papanicolaou method. .
3. The study shows that in our hands the false positive and false negative rate was slightly lower in the fluorescent method than in the Papanicolaou method.
4. Further evidence is presented to show that the fluorescent method is quicker and easier as a screening method and has a real place in the screening for cervical cancer.
5. In addition to its cancer detection, it is also useful in diagnosing causes of vaginal discharge such as trichomonas and monilia.

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