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Transient newborn neutropenia immediately after chemotherapy during pregnancy: A case report

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±èÀº³ª ( Kim Eun-Na ) - ¼­¿ï´ëÇб³ Àǰú´ëÇÐ »êºÎÀΰúÇб³½Ç

ÇѰæÈñ ( Han kyung-Hee ) - ¼­¿ï´ëÇб³ Àǰú´ëÇÐ »êºÎÀΰúÇб³½Ç
±è¼ö¾Æ ( Kim Su-Ah ) - ¼­¿ï´ëÇб³ Àǰú´ëÇÐ »êºÎÀΰúÇб³½Ç
ÀüÁ¾°ü ( Jun Jong-Kwan ) - ¼­¿ï´ëÇб³ Àǰú´ëÇÐ »êºÎÀΰúÇб³½Ç

Abstract

ÀӽŠÁß ¹ß»ýÇÏ´Â ±Þ¼º¹éÇ÷º´Àº 75,000ÀӽŴç 1°ÇÀ¸·Î ¸Å¿ì µå¹°°í žÆÀÇ »ýÁ¸ °¡´É¼ºÀÌ ÀÖ´Â ÀӽŠÁ߱⿡ Áø´Ü¹ÞÀº ¹éÇ÷º´ »ê¸ðÀÇ Ä¡·á¿¡ ´ëÇÏ¿© Á¤¸³µÈ ¹Ù ¾øÀ¸³ª, ÃÖ±ÙÀÇ °æÇâÀº ÀӽŠÁß ±Þ¼º¹éÇ÷º´ ¹ß»ý ½Ã ¹éÇ÷º´ÀÇ Ä¡·á¸¦ Áö¿¬µÇÁö ¾Êµµ·Ï ¹Ù·Î ½ÃÇàÇÏ´Â °ÍÀÌ´Ù. ¿©·¯ ¿¬±¸¿¡¼­ Ç×¾ÏÈ­Çпä¹ýÀ» ½ÃÇà¹ÞÀº »ê¸ð¿Í ½Å»ý¾Æ ¸ðµÎ¿¡°Ô ¼º°øÀûÀÎ °á°ú¸¦ °¡Á®¿Ô´Ù°í º¸°íÇϰí ÀÖ´Ù. ±×·¯³ª ¹éÇ÷º´ ÀÚü ¹× ±× Ä¡·á·Î ÀÎÇÑ ºóÇ÷, Ç÷¼ÒÆÇ °¨¼Ò, È£Áß±¸ °¨¼Ò°¡ ¹ß»ýÇÒ ¼ö ÀÖ°í Ç×¾ÏÈ­Çпä¹ý Á÷ÈÄ Å¾ ½Å»ý¾Æ¿¡°Ôµµ È£Áß±¸ °¨¼Ò¸¦ ÀÏÀ¸Å³ ¼ö ÀÖÀ¸¹Ç·Î ÀӽŠÁß ±Þ¼º¹éÇ÷º´¿¡ ´ëÇÑ Ç×¾ÏÈ­Çпä¹ýÀ» ¹ÞÀº »ê¸ð¿Í ½Å»ý¾Æ¿¡°Ô ÁýÁß Ä¡·á°¡ ÇÊ¿äÇÏ´Ù. ÀúÀÚµéÀº ÀӽŠÁ߱⿡ ¹ß°ßµÈ ±Þ¼º¹éÇ÷º´ »ê¸ð°¡ Ç×¾ÏÈ­Çпä¹ý ÈÄ È£Áß±¸ °¨¼Ò¼º ¹ß¿­°ú ÇÔ²² Á¶±âÁøÅëÀÌ ¹ß»ýÇÏ¿´°í, Ç×¾ÏÈ­Çпä¹ý Á÷ÈÄ ºÐ¸¸µÈ ½Å»ý¾Æ¿¡°Ô ½É°¢ÇÑ È£Áß±¸ °¨¼ÒÁõÀÌ ³ªÅ¸³µÀ¸³ª ÁýÁß°üÂû ¹× Ä¡·á¿Í ÇÔ²² ¼º°øÀûÀ¸·Î ȸº¹ÇÏ¿´´ø 1¿¹¸¦ °æÇèÇÏ¿´±â¿¡ º¸°íÇÏ´Â ¹ÙÀÌ´Ù.

The incidence of acute leukemia in pregnancy is as low as 1 in 75,000 pregnancies. There is no established guideline for the treatment of leukemia during midtrimester pregnancy. But nowadays, consensus is not to delay the leukemia treatment with chemotherapy even in pregnancy. Many authors reported successful outcomes of mothers and newborns. Because of the leukemia itself and side effects of the chemotherapy, anemia, thrombocytopenia and neutropenia are commonly encountered in women treated with chemotherapy. With chemotherapy in utero just before the delivery, the newborn could be neutopenic. We report one case of midtrimester pregnant woman who took chemotherapy for leukemia and suffered from neutropenic fever and preterm labor. The newborn was neutropenic. However, both the mother and the baby were successfully recovered from neutropenia.

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ÀÓ½Å; ±Þ¼º¹éÇ÷º´; Ç×¾ÏÈ­Çпä¹ý; ½Å»ý¾Æ; È£Áß±¸ °¨¼ÒÁõ
Pregnancy; Acute leukemia; Chemotherapy; Newborn; Neutropenia
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KoreaMed
KAMS