ÀڱðæºÎ »óÇÇ ³» Á¾¾ç¿¡¼ ÀÎÀ¯µÎÁ¾¹ÙÀÌ·¯½º °¨¿°°ú Ŭ¶ó¹Ìµð¾Æ Æ®¶óÄÚ¸¶Æ¼½ºÀÇ °¨¿°¿¡ ´ëÇÑ ÀÓ»óÀû °íÂû
The study of association between human papillomavirus and Chlamydia trachomatis infection in cervical intraepithelial neoplasia
¾çÁ¤¼± ( Yang Jung-Sun ) - ´Ü±¹´ëÇб³ Àǰú´ëÇÐ »êºÎÀΰúÇб³½Ç
Á¤À±Èñ ( Jeong Yun-Hee ) - ´Ü±¹´ëÇб³ Àǰú´ëÇÐ »êºÎÀΰúÇб³½Ç
±èÁ¾¼ö ( Kim Jong-Soo ) - ´Ü±¹´ëÇб³ Àǰú´ëÇÐ »êºÎÀΰúÇб³½Ç
Abstract
¸ñÀû: º» ¿¬±¸´Â human papillomavirus (HPV) °¨¿°°ú Ŭ¶ó¹Ìµð¾Æ °¨¿°ÀÌ ÀڱðæºÎ ÀÌÇü¼º¿¡ ¿µÇâÀ» ¹ÌÄ¡´ÂÁö ¾Ë¾Æº¸°íÀÚ ÇÏ¿´´Ù.
¿¬±¸ ¹æ¹ý: ÀڱðæºÎ ¾×»ó¼¼Æ÷Áø °Ë»ç¿¡¼ ºñÁ¤»óÀ¸·Î Áø´ÜµÈ ȯÀÚ 374¸íÀ» ´ë»óÀ¸·Î Á¶Á÷ÇÐÀû °Ë»ç¿Í HPV ¹× Ŭ¶ó¹Ìµð¾Æ °¨¿°ÀÇ »ó°ü°ü°è¸¦ ¿¬±¸ÇÏ¿´´Ù.
°á°ú: Á¶Á÷ÇÐÀû °Ë»ç°á°ú cervical intraepithelial neoplasia (CIN) 2°¡ 16¸í, CIN 3°¡ 55¸í, carcinoma in situ (CIS)°¡ 53¸íÀ̾úÀ¸¸ç ¾×»ó ¼¼Æ÷Áø °Ë»ç¿¡¼´Â atypical squamous cells of undetermined significance¿´À¸³ª high-grade squamous intraepithelial lesions ÀÌ»óÀÎ °íµî±Þ º´º¯ÀÌ 22¸íÀ̾úÀ¸¸ç, low-grade squamous intraepithelial lesions±º¿¡¼µµ 7¸íÀÌ °íµî±Þ º´º¯À¸·Î ÆÇÁ¤µÇ¾ú´Ù. HPV °¨¿°±ºÀº 235¸íÀ̰í Ŭ¶ó¹Ìµð¾Æ °¨¿°±ºÀº 31¸í(8.3%)À̸ç, µÎ ±ºÀÇ µ¿½Ã°¨¿°Àº 25¸í(6.7%)ÀÇ ºóµµ¸¦ º¸¿´À¸¸ç µ¿½Ã °¨¿°±º°ú Á¶Á÷ÇÐÀû º´º¯ÀÇ ¾Ç¼ºµµÀÇ »ó°ü°ü°è´Â ¾ø¾ú´Ù(P=0.089). HPV °¨¿°°ú Ŭ¶ó¹Ìµð¾Æ °¨¿°¿¡´Â ¼±ÈÄ °ü°è´Â ¸íÈ®ÇÏÁö ¾ÊÀ¸³ª P=0.022·Î µÎ ±º °£¿¡ À¯ÀÇÇÑ »ó°ü°ü°è°¡ Á¸ÀçÇÑ´Ù°í º¼ ¼ö ÀÖ´Ù. °íµî±Þ CIN±º¸¸À» ´ë»óÀ¸·Î HPV ¹× Ŭ¶ó¹Ìµð¾Æ °¨¿°ÀÇ Åë°èÀû À¯ÀǼºÀº P=0.157·Î Åë°èÀû À¯ÀǼºÀº ¾ø¾úÀ¸¸ç, °íÀ§Çè HPV °¨¿°°ú Ŭ¶ó¹Ìµð¾Æ °¨¿° ¶ÇÇÑ P=0.195·Î Åë°èÀû »ó°ü°ü°è´Â ¾ø¾ú´Ù.
°á·Ð: ÀڱðæºÎ »óÇdz» Á¾¾ç ȯÀÚ¿¡¼ HPV °¨¿°Àº ±× ¿ªÇÒÀÌ ³Î¸® ¾Ë·ÁÁ® ÀÖÀ¸³ª Ŭ¶ó¹Ìµð¾Æ °¨¿°°úÀÇ ¿¬°ü¼º¿¡ ´ëÇØ¼´Â ¾ÆÁ÷ ´õ ¸¹Àº ¿¬±¸°¡ ÀÖ¾î¾ß ÇÒ °ÍÀ¸·Î »ý°¢µÈ´Ù.
Objective: The aim of this study is to comparing the prevalence and correlationships between human papillomavirus (HPV) and Chlamydia trachomatis (CT) infection in cervical samples among women with abnormal cervical cytology.
Methods: This study was included three hundred seventy four patients with a abnormal liquid-based cytology in Dankook University hospital. All of them underwent HPV DNA test and CT analysis with polymerase chain reaction. All patients also went through colposcopic directed cervical biopsies or Loop Electrosurgical Excision Procedure, conization. The histo-pathologic results were classified as normal, cervical intraepithelial neoplasia (CIN) 1, CIN 2, CIN 3 and carcinoma in situ (CIS).
Results: Abnormal liquid-based cytology patients were pathologically proven to have CIN. Among 374 patients, the number of within normal limits (chronic cervicitis) and koilocytosis was 186 cases (49.7%), CIN 1, 64 cases (17.1%), CIN 2 16 cases (4.3%) CIN 3, 55 cases (14.7%), and CIS, 53 cases (14.2%). HPV DNA positive patients were 235 cases and HPV DNA negative patients were 139 cases. The impact of CT infection seems not to interfere with the development or even the progression of CIN. Thirty one patients had positive infection of CT (8.3%) and 343 patients were negative infection of CT (91.7%). Both HPV and CT positive infected patients were 25 cases (6.7%) in abnormal cytologic women. The correlation between HPV and CT DNA positive among women with abnormal cytology was statistically significant. (P=0.022)
Conclusion: This study suggests that CT infection is associated with HPV infection, but the clinical significance of the association between CT and HPV infection remains to be elucidated.
Ű¿öµå
ÀڱðæºÎ ÀÌÇü¼º; ÀÎÀ¯µÎÁ¾ ¹ÙÀÌ·¯½º; Ŭ¶ó¹Ìµð¾Æ Æ®¶óÄÚ¸¶Æ¼½º; ÀڱðæºÎ ¾×»ó¼¼Æ÷Áø°Ë»ç
Cervical intraepithelial neoplasia; Human papilloma virus; Chlamydia trachomatis; Liquid-based cytology
KMID :
0358420100530121100
DOI :
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