°æÁõ ÀڱðæºÎ»óÇdz»Á¾¾çÀÇ p16, Ki-67, p63, CK17 ¸é¿ªÁ¶Á÷ÈÇп°»ö¾ç»ó°ú ¿¹ÈÄ¿ÍÀÇ °ü°è
THE PROGNOSTIC SIGNIFICANCE OF P16, KI-67, P63, AND CK17 EXPRESSION DETERMINED BY IMMUNOHISTOCHEMICAL STAINING IN CERVICAL INTRAEPITHELIAL NEOPLASIA 1
±è¼ö¹Ì ( Kim Su-Mi ) - °¡Å縯´ëÇб³ Àǰú´ëÇÐ ¼º¸ðº´¿ø »êºÎÀΰú
ÀÌÁ¤ÀÇ ( Lee Jung-Uee ) - °¡Å縯´ëÇб³ Àǰú´ëÇÐ ´ëÀü¼º¸ðº´¿ø º´¸®°úÇб³½Ç
( Lee Dae-Woo ) - °¡Å縯´ëÇб³ Àǰú´ëÇÐ »êºÎÀΰúÇб³½Ç
±è¹ÎÁ¤ ( Kim Min-Jung ) - °¡Å縯´ëÇб³ Àǰú´ëÇÐ »êºÎÀΰúÇб³½Ç
ÀÌÇØ³² ( Lee Hae-Nam ) - °¡Å縯´ëÇб³ Àǰú´ëÇÐ »êºÎÀΰúÇб³½Ç
Abstract
¸ñÀû: °æÁõ ÀڱðæºÎ»óÇdz»Á¾¾ç(cervical intraepithelial neoplasia [CIN] 1)ÀÇ p16, Ki-67, p63, cytokeratin (CK) 17 ¸é¿ªÁ¶Á÷ÈÇп°»ö¾ç»ó°ú ÀÓ»ó ¿¹ÈÄ¿ÍÀÇ °ü°è¸¦ Æò°¡ÇϰíÀÚ ÇÏ¿´´Ù.
¿¬±¸¹æ¹ý: 33¸íÀÇ CIN 1 ȯÀÚµé·ÎºÎÅÍ ¾òÀº ÀڱðæºÎÁ¶Á÷À» p16, Ki-67, p63, CK17 ¸é¿ªÁ¶Á÷ÈÇп°»öÀ» ÇÏ¿´´Ù, ¸é¿ª¿°»ö¾ç»ó°ú CIN 1ÀÇ ÀÓ»ó¿¹ÈÄ ¸¦ ºñ±³ÇÏ¿´´Ù.
°á°ú: p16 ¸é¿ª¿°»ö¿¡ À½¼ºÀΠȯÀÚ 18¸í Áß 17¸í(94.4%)¿¡¼ ÀÌÈÄ CIN 1 º´º¯ÀÌ ¼Ò½ÇµÇ¾úÀ¸¸ç ³ª¸ÓÁö ÇÑ ¸í(5.6%)¿¡¼¸¸ º´º¯ÀÌ Áö¼ÓµÇ¾ú ´Ù. Ki-67 ¸é¿ª¿°»ö¿¡ À½¼ºÀΠȯÀÚ 16¸í Áß 15¸í(93.8%)¿¡¼ ÀÌÈÄ º´º¯ÀÌ ¼Ò½ÇµÇ¾ú°í ÇÑ ¸í(6.3%)¿¡¼¸¸ º´º¯ÀÌ Áö¼ÓµÇ¾ú´Ù. P16°ú Ki- 67 ¸é¿ª¿°»ö À½¼ºÀº º´º¯ÀÇ ¼Ò½Ç°ú À¯ÀÇÇÑ °ü°è¸¦ º¸¿´´Ù(P =0.004¿Í P =0.017). p16°ú Ki-67 ¸é¿ª¿°»ö¿¡ ¸ðµÎ À½¼ºÀΠȯÀÚ 15¸í Áß 14¸í (93.3%)¿¡¼ º´º¯ÀÌ ¼Ò½ÇµÇ¾ú°í ³ª¸ÓÁö ÇÑ ¸í(6.7%)¿¡¼¸¸ º´º¯ÀÌ Áö¼ÓµÇ¾ú´Ù. P63°ú CK17 ¸é¿ª¿°»ö¾ç»óÀº ÁúȯÀÇ ÀÓ»ó¾ç»ó°ú ´Â À¯ÀÇÇÑ °ü°è°¡ ¾ø¾ú´Ù(P =0.149¿Í P =0.642). p16 ¸é¿ª¿°»ö ¾ç¼ºÀÎ 13¸íÀÇ È¯ÀÚ Áß 10¸í(76.9%)ÀÌ °íÀ§Çè ÀÎÀ¯µÎÁ¾¹ÙÀÌ·¯½º (human papillomavirus, HPV)¿¡ °¨¿°µÈ »óÅ¿´´Ù. °íÀ§Çè HPV °¨¿°Àº p16 ¸é¿ª¿°»ö ¾ç¼º°ú À¯ÀÇÇÑ °ü°è°¡ ÀÖ¾ú´Ù(P =0.049).
°á·Ð: CIN 1ÀÌ p16À̳ª Ki-67 ¸é¿ª¿°»ö À½¼ºÀ» º¸ÀÏ °æ¿ì º´º¯ÀÌ ÀúÀý·Î ¼Ò½ÇµÇ´Â °æÇâÀ» º¸¿´´Ù. ¹Ý¸é P63°ú CK17Àº CIN 1ÀÇ ÀÓ»ó¾ç»ó°ú °ü °è°¡ ¾ø¾ú´Ù.
Objective : To evaluate the prognostic signifi cance of p16, Ki-67, p63, and cytokeratin (CK) 17 expression determined by immunohistochemical staining in cervical intraepithelial neoplasia (CIN) 1.
Methods: Biopsy tissue samples from 33 patients diagnosed with CIN 1 were stained immunohistochemically for p16, Ki-67, p63, and CK17. The staining results were correlated with the clinical course of the disease.
Results: Seventeen of 18 (94.4%) p16-negative patients experienced regression, and only 1 patient (5.6%) developed persistent disease. Fifteen of the 16 (93.8%) Ki-67-negative patients experienced regression, and 1 patient (6.3%) developed persistent disease. Negative p16 and Ki-67 expression correlated signifi cantly with disease regression (P =0.004 and P =0.017, respectively). Fourteen of 15 (93.3%) patients negative for both p16 and Ki-67 experienced regression, and 1 patient negative for both p16 and Ki-67 (6.7%) developed persistent disease. The expression levels of p63 and CK17 were not signifi cantly associated with disease regression or persistence (P =0.149 and P =0.642, respectively). Ten of the 13 (76.9%) p16-positive patients had a high-risk HPV infection. Highrisk HPV infection was signifi cantly associated with p16 expression (P =0.049).
Conclusion: CIN 1 with p16- or Ki-67-negative immunohistochemical staining was associated with spontaneous disease regression. The p63 and CK17 expression patterns were not related to the behavior of CIN 1.
Ű¿öµå
°æÁõ ÀڱðæºÎ»óÇdz»Á¾¾ç
p16; Ki-67; p63; CK17
KMID :
0358420110540040184
DOI :
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