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High risk type human papillomavirus indicates increasing high grade intraepithelial lesion incidence in cytological low grade squamous intraepithelial lesion patients
¹Ú¿µÇÑ ( Park Young-Han ) - ÇѸ²´ëÇб³ Àǰú´ëÇÐ »êºÎÀΰúÇб³½Ç
ÀÓäÃá ( Rhim Chae-Chun ) - ÇѸ²´ëÇб³ Àǰú´ëÇÐ »êºÎÀΰúÇб³½Ç
°Á¤¹è ( Kang Jung-Bae ) - ÇѸ²´ëÇб³ Àǰú´ëÇÐ »êºÎÀΰúÇб³½Ç
ÀåºÀ¸² ( Jang Pong-Rheem ) - ÇѸ²´ëÇб³ Àǰú´ëÇÐ »êºÎÀΰúÇб³½Ç
±èÈ«¹è ( Kim Hong-Bae ) - ÇѸ²´ëÇб³ Àǰú´ëÇÐ »êºÎÀΰúÇб³½Ç
À̱ٿµ ( Lee Keun-Young ) - ÇѸ²´ëÇб³ Àǰú´ëÇÐ »êºÎÀΰúÇб³½Ç
¹ÚÂùÀº ( Park Chan-Eun ) - ÇѸ²´ëÇб³ Àǰú´ëÇÐ »êºÎÀΰúÇб³½Ç
³ëÀǼ± ( Rho Eui-Seon ) - ÇѸ²´ëÇб³ Àǰú´ëÇÐ »êºÎÀΰúÇб³½Ç
Á¶¿ë ( Jo Yong ) - ÇѸ²´ëÇб³ Àǰú´ëÇÐ »êºÎÀΰúÇб³½Ç
ÀÌ¿ë¿ì ( Lee Yong-Woo ) - ÇѸ²´ëÇб³ Àǰú´ëÇÐ »êºÎÀΰúÇб³½Ç
¾ç¼ºÃµ ( Yang Seong-Cheon ) - ÇѸ²´ëÇб³ Àǰú´ëÇÐ »êºÎÀΰúÇб³½Ç
ÃÖ¼ö¶õ ( Choi Soo-Ran ) - Áß¾Ó´ëÇб³ Àǰú´ëÇÐ ¾à¸®Çб³½Ç
±è¼ºÁÖ ( Kim Sung-Joo ) - ÇѸ²´ëÇб³ Àǰú´ëÇÐ »êºÎÀΰúÇб³½Ç
Abstract
¸ñÀû : ÀÎÀ¯µÎÁ¾¹ÙÀÌ·¯½º´Â ÀڱðæºÎ¾ÏÀÇ ¿øÀÎÀÌ´Ù. Papanicolaou °Ë»ç´Â ÀڱðæºÎ¾ÏÀÇ ¼±º°°Ë»çÀÌ´Ù. ÀϺΠ¼¼Æ÷°Ë»ç»ó Àúµî±Þ»óÇdz»º´º¯Àº °íµî±Þ»óÇdz»º´º¯À̳ª ÀڱðæºÎ¾ÏÀ¸·ÎÀÇ Áß°£´Ü°è¶ó°í ÇÒ ¼ö ÀÖ´Ù. º» ¿¬±¸´Â Àúµî±Þ»óÇdz» º´º¯¿¡¼ÀÇ °íÀ§Ç豺 ÀÎÀ¯µÎÁ¾¹ÙÀÌ·¯½ºÇüÀÇ ¾ç¼ºÀÌ °®´Â Àǹ̸¦ ±Ô¸íÇϱâ À§ÇÑ ¿¬±¸ÀÌ´Ù.
¿¬±¸ ¹æ¹ý : ÇѸ²´ëÇб³¼º½Éº´¿øÀ» 2006³â 2¿ùºÎÅÍ 2008³â 2¿ù±îÁö ¹æ¹®ÇÏ¿© ¿øÃßÀýÁ¦¼úÀ» ¹ÞÀº 200¸íÀÇ È¯ÀÚÀÇ Àǹ«±â·ÏÀ» ÈÄÇâÀûÀ¸·Î °ËÅäÇÏ¿´´Ù. DNA microarray¸¦ ÀÌ¿ëÇÑ ÀÎÀ¯µÎÁ¾¹ÙÀÌ·¯½º °Ë»ç°á°ú¸¦ 20¸íÀÇ Àúµî±Þ»óÇdz»º´º¯ ȯÀÚ¿¡¼ È®ÀÎÇÒ ¼ö ÀÖ¾ú´Ù. X2-°Ë»ç¿Í student-t°Ë»ç¸¦ »ç¿ëÇÏ¿´´Ù.
°á°ú : ¼¼Æ÷°Ë»ç»ó Àúµî±Þ»óÇdz»º´º¯(low grade squamous intraepithelial lesion, LSIL) ȯÀÚ¿¡¼, ÀÎÀ¯µÎÁ¾¹ÙÀÌ·¯½º °íÀ§ÇèÇü ¾ç¼ºÀΠȯÀÚ´Â 16/20¸í(80%)À̸ç, ÀÎÀ¯µÎÁ¾¹ÙÀÌ·¯½º ÀúÀ§ÇèÇü ¾ç¼ºÀΠȯÀÚ´Â 1/20¸í(5%)À̾ú´Ù. ¼¼Æ÷°Ë»ç»ó LSIL ȯÀÚ¿¡¼ ¿øÃß»ý°Ë¼ú ÈÄ Á¶Á÷ÇÐÀû Áø´Ü¿¡ µû¸¥ ºÐ·ù´Â cervical intraepithelial neoplasia 1 (CIN 1) 16/26¸í(61.5%),CIN2 2/26¸í(7.7%), CIN3 5/26¸í(19.2%), CIS 1/26¸í(3.8%)À̾ú°í, CIN2 ÀÌ»óÀÇ º´º¯Àº 8/26¸í(30.8%)¿´´Ù. ÀÎÀ¯µÎÁ¾ °íÀ§ÇèÇü ¾ç¼ºÀÎ 16¸íÀÇ È¯ÀÚ´Â °íµî±Þ»óÇdz»º´º¯(high grade intraepitheliallesion, HSIL) ÀÌ»óÀÌ 6/16¸í(37.5%)À̾ú´Ù. ÀÎÀ¯µÎÁ¾¹ÙÀÌ·¯½º °íÀ§ÇèÇü À½¼ºÀÎ ¼¼Æ÷°Ë»ç»ó LSILÀÎ 10¸íÀÇ È¯ÀÚ¿¡¼ Á¶Á÷°Ë»ç»ó HSIL ÀÌ»óÀº 2/10¸í(20%)À̾ú´Ù. ÀÎÀ¯µÎÁ¾¹ÙÀÌ·¯½º °íÀ§ÇèÇüÀÇ À¯º´·üÀº LSIL°ú HSIL¿¡¼ ºñ½ÁÇÏ¿´´Ù.
°á·Ð : LSIL°ú HSIL¿¡¼ ÀÎÀ¯µÎÁ¾¹ÙÀÌ·¯½º °íÀ§ÇèÇüÀÇ À¯º´·üÀº LSIL°ú HSIL¿¡¼ ºñ½ÁÇÏ¿´´Ù. °íÀ§ÇèÇü ¹ÙÀÌ·¯½º ¾ç¼ºÀÎ LSIL¿¡¼ HSILÀ̳ª °æºÎ¾ÏÀÇ ºóµµ´Â Áõ°¡ÇÏ´Â °Íó·³ º¸ÀδÙ. LSILȯÀÚ¿¡¼ ÀÎÀ¯µÎÁ¾¹ÙÀÌ·¯½º °Ë»ç´Â ¼¼Æ÷°Ë»ç»ó LSILÀÇ ¼º°Ý°ú ¿¹Èĸ¦ ±¸º°ÇÏ´Â µ¥ ¸Å¿ì µµ¿òÀÌ µÇ´Â °Ë»ç·Î º¸À̹ǷΠ¹Ýµå½Ã ½ÃÇàµÇ¾î¾ß ÇÒ °ÍÀÌ´Ù.
Objective: Human papillomavirus (HPV) is known as the causal agent of cervical cancer. The Papanicolaou smear is the most popular screening tool for cervical cancer. Some cytological low grade squamous intraepithelial lesions (LSILs) are in the developmental stage of high grade intraepithelial lesions (HSILs) and cervical cancer metaphases. Our purpose is to disclose the significance of high risk type (HRT) HPV in LSIL.
Methods: Documentation of 200 cases of cone biopsy at Hallym University Sacred Heart Hospital from February 2006 to February 2008 was reviewed retrospectively. HPV typing with DNA microarray results were found in 20 of the LSIL patients. Chi-square and student-t tests were used in the statistical analysis.
Results: In the cytological LSIL patients, HRT-HPV positive patients were 16/20 (80%) and one low risk type (LRT) HPV positive patient was 1/20 (5%). In the cytological LSIL patients, postoperative pathological diagnoses were cervical intraepithelial neoplasia 1 (CIN 1) 16/26 (61.5%), CIN2 2/26 (7.7%), CIN3 5/26 (19.2%), carcinoma in situ 1/26 (3.8%). Among the 16 HRT-HPV positive patients, there were six that were above HSIL 6/16 (37.5%) in pathologic diagnoses. In the HRT-HPV negative 10 cytologic LSIL patients, there were two that were above HSIL 2/10 (20%) in pathologic diagnoses. HRT-HPV prevalences were not significantly different between LSIL and HSIL.
Conclusion: In HRT-HPV positive LSIL, the risk of HSIL or cancer of the cervix seems to be increasing. The HPV test is helpful in LSIL patient strategies and should be done in LSIL patients in order to discriminate between the nature and prognosis of cytological LSIL.
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Human papillomavirus;Low grade squamous intraepithelial lesion.
KMID :
0358420110540080435
DOI :
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