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去勢 및 性홀몬投與가 男性性器組織電解質 分布狀態에 미치는 影響

Effect of castration and hormone administration on the electrolyte distribution in gonadal tissues of male rabbit.

대한생화학회잡지 1964년 1권 1호 p.15 ~ 24
박병원 (  ) - 서울대학교 의과대학 생화학교실 수도의과대학 비뇨기과학교실

Abstract


One hundred and twenty rabbits were divided- into 8 groups as follows:
Group 1: Control (non castrated Group 2: Castration control (castrated Group 3; Castrated and estrogen injected Group 4: Castrated and testosterone injec Group 5: Cash a.ted and progesterone injected Group 6: Non castrated and estrogen injected Group 7: Non castrated and testosterone injected Group 8 Non castrated and progesterone injected -Fourteen days after castration, each rabbit in group 3, 4
units of estrogen, 400 units of eack testosterone and progesterone daily for 3 consecutive days.
Three days after the final injection, they were killed. All , of the animals were sacrificed ,by means of cardiac puncture. The blood sample thus obtained was used for serum electrolyte determination. Immediately after sacrificing the animals, seminal vesicle, prostate and testes (non castrated animals) were taken out for the determination
Sodium and potassium in serum and tissue were ,determined by means of Beard flame photometer using lithium nitrate as internal standard. Serum chloride was analysed by the method of Schales and Schales, while tissue chloride after Van Slyke.
The results of this investigation were as follows:
1. The changes in the contents of water, Na, K and Cl in the serum of rabbits castrated or injected with estrogen, testosterone and progesterone were determined as being insignificant.
2. Injection of testosterone and progesterone into non castrated rabbits indicated little changes in the water contents. Sodium contents slightly decreased, whereas potassium and chloride contents increased to a degree unremarkable.
3. ´The water° contents-in the seminal vesicle of non castrated rabbits did. not. coreespond to the administration of hormones In the testosterone administration group, an increase of Na contents was noted along with a subsequent increase. in the total
Na+K.
The electrolyte contents in the seminal vesicle of castrated rabbit group remarkably decreased presenting a significant ;hypoelectrolyte state, in the restoration of which to a normal level, testosterone injection provided: the ,most effective result with progesterone running up and estrogen following in the precedence of effect.
4. The effect of testosterone administration on the electrolyte in the prostate of a non castrated rabbits was more remarkable than seen in ,the case of the prostate of non castrated rabbit. Progesterone preceded estrogen as an agent of promoting the formation of electrolyte contents as in the foregoing investigation.
Although the prostatic tissue of castrated rabbits showed only a ` minor difference in water contents from that of non castrated ones, it was noted the electrolyte contents had remarkably decreased as in the seminal vesicle.
The injection of hormone proved testosterone to be the most effective agent in the formulation of electrolyte contents with progesterone and estrogen -following:. again in the same fashion as in the two foregoing investigations involving such promoters.

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