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실험적 요세관증에 있어서 신장염유발에 관한 병리조직학적 연구

Histopathological Studies on Nephritis Produced in Experimental Tubular Nephrosis

대한수의학회지 1967년 7권 2호 p.19 ~ 24
임창형 (  ) - 서울대학교 농과대학

Abstract


Normal Albino rats were received glycerin via subcutaneously and Staphylococcus aureus intravenously. The microorganism was coagulase-positive and non-hemolytic. The rats received glycerin alone showed an acute tubular nephrosis, and the others such as glycer in induced nephrotic rats showed a number of different findings: At ◎ hours of the bacterial injection, in medulla, the bacterial clumps and inflammatory cell infiltration, and microabscesses with retrogressive changes of proximal convoluted tubulles were observed. The suppurative inflammation was observed in days. Five weeks after the initial innoulation of the organism kidney was shown restoration to a histologically normal cortex. The proliferation of fibrous connective tissue and small numbers of chronic inflammatory cells were observedin the medulla where an acute inflammatory process was enhanced presumably.
On the other band, the Albino rats administered Staphyloceccus aureus alone resulted in a moderate degree of vacuolization in ◎oximal convoluted tubules and a number of casts in the early stage. No bacterial clumps and microabscesses were observed in the rats.

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