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Cell Based Treatment for Middle Age Patients with Osteoarthritis

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ÃÖ³²È« ( Choi Nam-Hong ) - À»ÁöÀǰú´ëÇб³ ³ë¿øÀ»Áöº´¿ø Á¤Çü¿Ü°ú

Á¤À¯ÈÆ ( Jung Yu-Hun ) - À»Áö´ëÇб³ Àǰú´ëÇÐ ³ë¿øÀ»Áöº´¿ø Á¤Çü¿Ü°úÇб³½Ç

Abstract

¿¬°ñ ¼Õ»óÀ» Ä¡·áÇÏ´Â ¹æ¹ýÀ¸·Î ¿©·¯ ¹æ¹ýÀÌ ½ÃÇàµÇ°í ÀÖÁö¸¸, ¾ÆÁ÷±îÁöµµ Á¶Á÷ÇÐÀûÀ¸·Î, »ý¿ªÇÐÀûÀ¸·Î ÃÊÀÚ¿¬°ñ°ú À¯»çÇÑ ¿¬°ñÀÌ º¹±¸µÇ°í ÀÖ¾î, ±âÁ¸ÀÇ Ä¡·á¹ýµéÀÇ ÀÓ»ó°á°ú´Â ½Å·ÚÇϱ⠾î·Á¿ü´Ù. ÃÊÀÚ¿¬°ñ¿¡ ±ÙÁ¢ÇÑ »ý¿ªÇÐÀû, Á¶Á÷ÇÐÀû ¼º»óÀ» °¡Áø ¿¬°ñÀ» Àç»ýÇϱâ À§ÇÏ¿© ¼¼Æ÷Ä¡·á°¡ ÃÖ±Ù µîÀåÇÏ¿´´Ù. º»³í¹®¿¡¼­´Â ¿¬°ñ¼¼Æ÷¸¦ ÀÌ¿ëÇÏ¿© ÃÖ±Ù¿¡ ½ÃµµµÇ°í ÀÖ´Â ¿¬°ñ °á¼Õ¿¡ ´ëÇÑ ¿©·¯ Ä¡·á¹ý°ú ±× ÀÓ»óÀû Àû¿ë¿¡ ´ëÇØ ¾Ë¾Æº¸°íÀÚ ÇÑ´Ù.

While many treatments have been performed to repair the chondral defects during last two decades, most of the repaired tissue has shown fibrocartilage or hyaline-like cartilage. Therefore, the clinical outcomes of conventional treatments are unrealiable and unpredictable. Cell-based treatments have recently emerged to regenerate the cartilage with better biomechanical properties and histological quality so that it resembles nature hyaline cartilage. This review discusses the current methodology of the cell-based treatments and their clinical outcomes.

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Cell;Osteoarthritis
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KCI
KoreaMed
KAMS