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Alpha-Chymotrypsin 및 Trypsin의 家兎角膜에 대한 傷害

The Effects of Alpha-Chymotrypsin and Trypsin on the Rabbit´s Cornea

대한안과학회지 1964년 5권 2호 p.37 ~ 40
강래열 (  ) - 서울대학교 의과대학 안과학교실

Abstract


The posterior surface of the rabbit´s cornea was scraped by a, spatula or incised by a cy totome, followed by injection of alpha-chymotrypsin, or trypsin into the anterior chamber. The concentration of enzymes used were 5mg/cc and 0 5mg/cc of alpha-chymotrypsin and 5.000 Anson unit/cc and 500unit/cc of trypsin. Three minutes after the introduction of enzymes into the anterior chamber, irrigation of the anterior chamber with normal saline was performed.
The cornea was examined macroscopically and biomicroscopically for about 3 weeks. Histologicai examination was done on the 3rd and the 11th post-operative days. Tile cornea was affected more intensively and extensively when the stroma was injured than when only the endothelium was inturned. Alpha-chymotrypsin was more toxic to the cornea than trypsin and led sometimes to a corneal perforation.

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