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網膜糖量이 網膜血流遮斷에 依한 ERG變化에 미치는 影響

The Significance of the Glucose Content of the Retina in the Alteration of the B-Potential Induced by Retinal Ischemia

대한안과학회지 1965년 6권 1호 p.15 ~ 21
 ( Yawm Han-Soo ) - 서울대학교 의과대학 안과학교실

Abstract


The experiments were performed on albino rabbits in which retinal ischemia had been produced by elevating the intraocular pressure to 120 mmHg by canulation of the anterior chamber and serial electroretinograms were recorded. The animals were divided into 3 groups; the first served as a normal control, the second received 30cc of 50% glucose solution intravenously, and the third received 2 units of insulin intramuscularly.
The light stimuli used was 200 lux at the animal´s eye and its duration was 0.1 second.
The contents of glucose and glycogen together were shown in table 1 and figure 1. The content was the greatest in group II and the least in group III.
After elevation of the intraocular pressure, b-wave gradually decreased and finally extinguished. The disappearance time of the b-wave in 3 groups of animals was shown in table 3 and figure 3. The survival time of the b-wave was longest in group II and shortest in group III.
After 15 minutes of retinal ischemia, the intraocular pressure was returned to 15mmHg and the retinal blood flow was restored. The b-wave reappeared and the time at which b-wave recovers 50% of the original amplitude was shown in table 4 and figure 4. The b-wave recovers the quickest in group 2 animals and latest in group 3.
In conclusion, when the glucose content of the retina is high, the resistance of the b-wave against the retinal ischemia is high and its recovery after restoration of the blood flow is quick.
The significance of the glucose content of the retina and its role in retinal metabolism were discussed.

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