잠시만 기다려 주세요. 로딩중입니다.

血管擴張劑 및 收縮劑가 脈絡膜血流量에 미치는 影響

Effect of Vasomotor Drugs on the Choroidal Blood Flow in Rabbits

대한안과학회지 1966년 7권 2호 p.19 ~ 26
洪承浩 (  ) - 서울大學校 醫科大學 眼科學敎室

尹源植 (  ) - 서울大學校 醫科大學 眼科學敎室

Abstract


The effect of intravenously administered vasoconstrictor (nor-epinephrine, ephedrine and posterior pituitary hormone) and vasodilator (papaverine, nicotinic acid and theophylline) drugs on the choroidal blood flow of rabbits was studied by the apparatus based on the principle of Grayson´s internal calorimetry.
Thermistors, as the sensing elements, were introduced into the suprachoroidal space ,of rabbits eye, and continuous determinations were performed up to 60 minutes after the administration.
Papaverine(2mg/kg), theophylline (5mg/kg and 50 mg/kg) and nicotinic acid (2Zmg/kg and 50 mg/kg) produced significant increase in the blood flow, papaverine and theophylline being the most powerful.
Among the vasoconstrictor drugs, posterior pituitary hormone produced profound and prolonged decrease in the blood flow, whereas nor-epinephrine and ephedrine increase the blood flow following transient decreases in the blood flow.
The relationships between blood pressure, intraocular pressure and choroidal blood flow, and the suggestions in the therapeutic applications to human eye were discussed.

키워드

원문 및 링크아웃 정보
 
등재저널 정보
KCI
KoreaMed
KAMS