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Azathioprine의 角膜移植反應抑制作用

Immunosuppression of Corneal Graft Reaction by Azathioprine

대한안과학회지 1967년 8권 3호 p.17 ~ 21
윤동호 (  ) - 서울대학교 의과대학 안과학교실

Abstract


1) The effectiveness of azathioprine (Imuran) in suppressing the immunogenic rejection of corneal grafts was studied by pathology.
2) The method of conjunctival implantation was used to produce neovascularization of the host cornea and the rejection of interlamellar aligraft and xenograft (rooster to rabbit) provided the experimental model against which the therapeutic efficacy of the drug was evaluated.
There is almost same pathological finding between interlamellar homograft and heterograft, but the rejection phenomena of the heterograft group is slightly severer than homograft group.
3) On comparing the graft rejection between control & treated group in homograft & heterograft, the reaction in control group is severer than treated group.
Microscopically, the cornea of treated group is almost transparent, but there are fibrosis of graft border, thickening of the host tissues & irregular arrangement of corneal lamellae, by microscopically.
4) On comparing between sensitized and non-sensitized group, no specific difference was observed by microscopically.

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