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Cytochrome C의 임상치료경험

The Effect of Cytochrome C in Ophthalmic Diseases

대한안과학회지 1968년 9권 1호 p.1 ~ 8
김희철 (  ) - 부산대학교 의과대학 안과학교실

김정자 (  ) - 부산대학교 의과대학 안과학교실
김광용 (  ) - 부산대학교 의과대학 안과학교실

Abstract


Cytochrome compounds which act as electron transfer agents in oxidation-reduction reactions. An important example is cytochrome c, which has a molecular weight of about 13,000 and contains one atom of iron per mol.
Our attempt is to evaluate clinically the therapeutic effect of cytochrome c on the healing wound of the lesions which supposed to be oxygen concentration is lowered than in normal tissues in tissue respiration, and it used in neuropathy, muscle paralysis, retinopathy, vitreous hemorrhage, corneal chemical burns in ophthalmology.
The patients included in the following series: They were five cases of retrobulbar optic neuritis, two cases of optic neuritis, one case of axial optic atrophy, two cases of simple optic atrophy, two cases of muscle paralysis, one case of central retinopathy, one case of chorio-retinal atrophy, one case of maculra degeneration, one case of diabetic retinopathy, one case of pigmentary degeneration of the retina, one case of vitreous hemorrhage, four cases of corneal chemical burn, and one case of corneal dystrophy.
After intra-dermal injection with cytochrome c, evaluated the allergic character and it was given intra-venous injection.
The results were as follows:
1) In total 23 cases, had excellent therapeutic effects on neuropathy, muscle paralysis,´ and corneal chemical burns.
2) In general, we found that it did not respond to central .retinopathy and diabetic retinopathy.
3) We experienced that it have response to the old lesions.
4) It was interested that the night blindness could be disappeared by cytochrome c use in pigmentary degeneration of the retina. Yet there remain certain problems so far unsolved.

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